Latent TB Infection (LTBI) - Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground
Rao, M. (Champalimaud Centre for the Unknown)
Ippolito, G. (National Institute for Infectious Diseases. Lazzaro Spallanzani)
Mfinanga, S. (National Institute of Medical Research Muhimbili)
Ntoumi, F. (University of Tübingen)
Yeboah-Manu, D. (Noguchi Memorial Institute for Medical Research)
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zumla, Alimuddin (University College London)
Maeurer, M. (Krankenhaus Nordwest)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Latent tuberculosis infection (LTBI) is established in over 90% of persons infected with Mycobacterium tuberculosis (Mtb), from whom new active TB cases will arise. Understanding the spatio-temporal dynamics of host immune responses in LTBI granulomas is essential to designing effective post-exposure therapies that inhibit progression to TB. Information arising from cancer studies and other modalities - where local chronic inflammation leads to immunopathology - can help provide insights into the biological pathways at play in LTBI granulomas. Translational studies using patient material as well as LTBI+ donor-derived tissue samples are instrumental in understanding the various components of granuloma dynamics, immunological landscapes therein and how this could help to identify therapeutic targets. Deep sequencing technologies may aid to decipher the genetic changes in lung granuloma and blood samples from LTBI+ individuals associated with progression to active TB disease. This may lead to advancement of development of targeted Host-Directed Therapies (HDTs) and their evaluation as adjunct TB therapies for improving treatment outcomes for LTBI and pulmonary TB.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Granuloma ; Host-directed therapies ; Immune landscape ; Latent tuberculosis infection ; Mutations
Published in:	International journal of infectious diseases, Vol. 80 (march 2019) , p. S58-S61, ISSN 1878-3511

DOI: 10.1016/j.ijid.2019.02.035
PMID: 30822547

4 p, 362.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles