Exploring the Role of Breast Density on Cancer Prognosis among Women Attending Population-Based Screening Programmes
Domingo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques)
Sala, Maria (Institut Hospital del Mar d'Investigacions Mèdiques)
Louro, Javier (Institut Hospital del Mar d'Investigacions Mèdiques)
Baré i Mañas, Marisa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Barata, Teresa (Servicio Canario de la Salud)
Ferrer, Joana (Hospital de Santa Caterina (Salt, Girona))
Carmona-Garcia, M. Carmen (Hospital Universitari de Girona Doctor Josep Trueta)
Comas Serrano, Mercè (Research Network on Health Services in Chronic Diseases (REDISSEC))
Castells, Xavier (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Institut Hospital del Mar d'Investigacions Mèdiques CAMISS Study Group

Data:	2019
Resum:	Background. Our aim was to assess the role of breast density on breast cancer mortality and recurrences, considering patient and tumour characteristics and the treatments received among women attending population-based screening programmes. Methods. We conducted a retrospective cohort study among women aged 50-69 years attending population-based screening programmes, diagnosed with invasive breast cancer between 2000 and 2009, and followed up to 2014. Breast density was categorised as low density (≤25% dense tissue), intermediate density (25-50%), and high density (≥50%). Cox proportional hazards regression models were fitted to estimate the adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) for death and recurrences, adjusting by patient characteristics, mode of detection (screen-detected vs. interval cancer), and tumour features. Results. The percentage of deaths and recurrences was higher among women with intermediate- and high-density breasts than among women with low-density breasts (p=0. 011 for death; p=0. 037 for recurrences). Adjusted Cox proportional hazards regression models revealed that women with intermediate- and high-density breasts had a higher risk of death than women with low-density breasts, being statistically significant for intermediate densities (aHR = 2. 19 [95% CI: 1. 16-4. 13], aHR = 1. 44 [95% CI: 0. 67-3. 1], respectively). No association was found between breast density and recurrences. Conclusions. Breast density was associated with a higher risk of death, but not of recurrences, among women participating in breast cancer screening. These findings reinforce the need to improve screening sensitivity among women with dense breasts and to routinely assess breast density, not only for its role as a risk factor for breast cancer but also for its potential influence on cancer prognosis.
Ajuts:	Ministerio de Economía y Competitividad PI15/00098 Ministerio de Ciencia e Innovación PS09/01153 Instituto de Salud Carlos III PI12/00387 Ministerio de Ciencia e Innovación PI11/01296 Ministerio de Economía y Competitividad PI16/00244 Ministerio de Economía y Competitividad RD16/0001/0013 Instituto de Salud Carlos III RD12/0001/0007 Instituto de Salud Carlos III RD12/0001/0015
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Journal of Oncology, Vol. 2019 (2019) , p. 1781762, ISSN 1687-8469

DOI: 10.1155/2019/1781762
PMID: 31885567

9 p, 1.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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