In silico characterization of human prion-like proteins : beyond neurological diseases
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Paladin, Lisanna (Università di Padua. Dipartimento di Scienze Biomediche)
Juan Blanco, Teresa (Institut de Recerca Biomèdica de Lleida)
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aloy, Patrick 1972- (Institució Catalana de Recerca i Estudis Avançats)
Tosatto, Silvio (Università di Padua. Dipartimento di Scienze Biomediche)
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")

Date:	2019
Abstract:	Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species. Here, we perform a stringent computational survey to identify prion-like proteins in the human proteome. We detected 242 candidate polypeptides and computationally assessed their function, protein-protein interaction networks, tissular expression, and their link to disease. Human prion-like proteins constitute a subset of modular polypeptides broadly expressed across different cell types and tissues, significantly associated with disease, embedded in highly connected interaction networks, and involved in the flow of genetic information in the cell. Our analysis suggests that these proteins might play a relevant role not only in neurological disorders, but also in different types of cancer and viral infections.
Grants:	European Commission 614944 Agencia Estatal de Investigación BIO2016-78310-R Agencia Estatal de Investigación BIO2016-77038-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Prion-like proteins ; Disease ; Protein-protein interaction ; Protein aggregation ; Amyloid ; Bioinformatics
Published in:	Frontiers in physiology, Vol. 10 (March 2019) , art. 314, ISSN 1664-042X

DOI: 10.3389/fphys.2019.00314
PMID: 30971948

12 p, 4.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles