Sexually transmitted infections in young people and factors associated with HIV coinfection : An observational study in a large city
Sentís, Alexis (Agència de Salut Pública de Barcelona)
Martin-Sánchez, Mario (Parc de Salut MAR de Barcelona)
Arando, Maider (Hospital Universitari Vall d'Hebron)
Vall, Martí (Hospital Universitari Vall d'Hebron)
Barberà, Maria Jesús (Hospital Universitari Vall d'Hebron)
Ocaña Rivera, Immaculada (Hospital Universitari Vall d'Hebron)
González Cordón, Ana (Hospital Clínic i Provincial de Barcelona)
Alsina, Mercè (Hospital Clínic i Provincial de Barcelona)
Martin-Ezquerra, Gemma (Hospital del Mar (Barcelona, Catalunya))
Knobel Freud, Hernando (Hospital del Mar (Barcelona, Catalunya))
Gurguí, Mercè (Institut d'Investigació Biomèdica Sant Pau)
Vives, Álvaro (Institut d'Investigació Biomèdica Sant Pau)
Coll, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Caylà, Joan A. (Fundació de la Unitat d'Investigació en Tuberculosi de Barcelona)
García de Olalla, Patricia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Objectives Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the epidemiological characteristics and trends in the incidence of gonorrhoea, syphilis, HIV and venereal lymphogranuloma (LGV) among 15-24-year-olds in Barcelona, and to determine factors associated with HIV coinfection. Design We performed a population-based incidence study covering the 2007-2015 period. Participants All new cases of STI - HIV, gonorrhoea, infectious syphilis and LGV - notified to the epidemiological surveillance system in Barcelona between 2007 and 2015. 1218 cases were studied: 84. 6% were men, 19. 3% were 15-19 years old and 50. 6% were born in Spain. Among men, 73. 7% were men who have sex with men (MSM); among women, 85. 6% were women that have sex with men. Primary and secondary outcomes Incidence of HIV, gonorrhoea, infectious syphilis and LGV. HIV coinfection. Results There was an increase in the incidence of gonorrhoea, from 1. 9 cases per 10 000 people in 2007 to 7. 6/10 000 in 2015 (p<0. 01), in MSM from 27. 1 to 228. 8/10 000 (p<0. 01). The incidence of syphilis increased from 0. 4/10 000 in 2007 to 3. 1/10 000 in 2015 (significant in men only, p<0. 01), in MSM from 18. 1 to 116. 9/10 000 (p<0. 01). The incidence of HIV showed a non-significant increase in men (p=0. 27), and that of LGV remained stable (p=0. 59). Factors associated with increased risk of HIV coinfection included being MSM (adjusted OR[ORa]=14. 14, 95% CI 3. 34 to 59. 91) and having >10 sexual partners (ORa=4. 11, 95% CI 1. 53 to 11. 01) or STI diagnosis during the previous 12 months (ORa=2. 06; 95% CI 1. 13 to 3. 77). Conclusions The incidence of gonorrhoea and syphilis among 15-24-year-olds increased, while HIV infection remained stable but with a high incidence among MSM. Being MSM, having sex with multiple partners and having a diagnosis of an STI in the previous 12 months were factors associated with HIV coinfection.
Note:	Altres ajuts: We thank all the reporting physicians who have contributed to the collection and quality of the information in the surveys. The Spanish Society of Epidemiology (SEE) for rewarding with 'VII Premio Emilio Perea' the work that gave rise to this article as the second best oral senior communication in the SEE Congress held in Barcelona in September 2017.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	BMJ open, Vol. 9 Núm. 5 (january 2019) , p. e027245, ISSN 2044-6055

DOI: 10.1136/bmjopen-2018-027245
PMID: 31061051

8 p, 853.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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Articles > Published articles