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Pàgina inicial > Articles > Articles publicats > MAP7 and MUCL1 are biomarkers of Vitamin D3-induced tolerogenic dendritic cells in multiple sclerosis patients |
Data: | 2019 |
Resum: | The administration of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases, such as multiple sclerosis (MS). Specifically, the use of vitamin D3 for the generation of tolDC (vitD3-tolDC) constitutes one of the most widely studied approaches, as it has evidenced significant immune regulatory properties, both in vitro and in vivo. In this article, we generated human vitD3-tolDC from monocytes from healthy donors and MS patients, characterized in both cases by a semi-mature phenotype, secretion of IL-10 and inhibition of allogeneic lymphocyte proliferation. Additionally, we studied their transcriptomic profile and selected a number of differentially expressed genes compared to control mature and immature dendritic cells for their analysis. Among them, qPCR results validated CYP24A1, MAP7 and MUCL1 genes as biomarkers of vitD3-tolDC in both healthy donors and MS patients. Furthermore, we constructed a network of protein interactions based on the literature, which manifested that MAP7 and MUCL1 genes are both closely connected between them and involved in immune-related functions. In conclusion, this study evidences that MAP7 and MUCL1 constitute robust and potentially functional biomarkers of the generation of vitD3-tolDC, opening the window for their use as quality controls in clinical trials for MS. |
Ajuts: | Instituto de Salud Carlos III PI14/01175 Instituto de Salud Carlos III PI16/01737 Instituto de Salud Carlos III PI17/01521 Agència de Gestió d'Ajuts Universitaris i de Recerca 02/2015 Agència de Gestió d'Ajuts Universitaris i de Recerca 01/2018 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-103 European Commission 779316 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Tolerogenic dendritic cells ; Multiple sclerosis ; Biomarkers ; Vitamin D3 ; Immune tolerance |
Publicat a: | Frontiers in immunology, Vol. 10 (June 2019) , art. 1251, ISSN 1664-3224 |
14 p, 1.9 MB |