Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer : a case control study
Pavlidou, Evangelia. (Geneva University Hospitals (Suïssa))
Daponte, Alexandros (University of Thessaly. Department of Obstetrics and Gynaecology. Faculty of Medicine)
Egea, Raquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dardiotis, Efthimios (University of Thessaly. Department of Neurology)
Hadjigeorgiou, Georgios M. (University of Thessaly. Department of Neurology)
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Agorastos, Theodoros (Hippokrateion General Hospital of Thessaloniki)

Data:	2016
Resum:	Background: the aim of the study was to evaluate the association of two SNPs of EVER1/2 genes' region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer in a Greek population. -Methods: among the 515 women who were included in the statistical analysis, 113 belong to the case group and present with precancerous lesions or cervical cancer (27 with persistent CIN1, 66 with CIN2/3 and 20 with cervical cancer) and 402 belong to the control group. The chi-squared test was used to compare the case and the control groups with an allelic and a genotype-based analysis. - Results: the results of the statistical analysis comparing the case and the control groups for all the SNPs tested were not statistically significant. Borderline significant difference (p value = 0. 079) was only found by the allelic model between the control group and the CIN1/CIN2 patients' subgroup for the polymorphism rs16970849. The comparison of the other case subgroups with the control group did not show any statistically significant difference. Conclusions: None of the SNPs included in the study can be associated with statistical significance with the development of precancerous lesions or cervical cancer.
Nota:	Ajuts: the present study was developed on a self-funding base, using a personal budget of Evangelia Pavlidou for the reagents used in the laboratory analysis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	EVER ; FAS ; Polymorphism ; Cervical cancer
Publicat a:	BMC Cancer, Vol. 16 (2016) , art. 923, ISSN 1471-2407

DOI: 10.1186/s12885-016-2960-3
PMID: 27899077

7 p, 406.2 KB

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