DisProt : intrinsic protein disorder annotation in 2020
Hatos, András (University of Padova. Department of Biomedical Sciences)
Hajdu-Soltész, Borbála (MTA-ELTE Lendület Bioinformatics Research Group. Department of Biochemistry. Eötvös Loránd University)
Monzon, Alexander M. (Department of Biomedical Sciences. University of Padova)
Palopoli, Nicolas (Departamento de Ciencia y Tecnología. Universidad Nacional de Quilmes-CONICET)
Álvarez, Lucía (Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biotecnológicas IIBIO. Universidad Nacional de San Martín)
Aykac-Fas, Burcu (Computational Biology Laboratory. Danish Cancer Society Research Center)
Bassot, Claudio (Department of Biochemistry and Biophysics and Science for Life Laboratory. Stockholm University. Box 1031)
Benítez, Guillermo I. (Departamento de Ciencia y Tecnología. Universidad Nacional de Quilmes-CONICET)
Bevilacqua, Martina (Department of Biomedical Sciences. University of Padova)
Chasapi, Anastasia (Centre for Research and Technology Hellas (Tessalònica, Grècia))
Chemes, Lucía Beatriz (Universidad de Buenos Aires. Departamento de Fisiología y Biología Molecular y Celular)
Davey, Norman E. (Institute of Cancer Research (Londres, Regne Unit))
Davidović, Radoslav (Laboratory for Bioinformatics and Computational Chemistry. Institute of Nuclear Sciences Vinca. University of Belgrade)
Dunker, A. Keith (Center for Computational Biology and Bioinformatics. Indiana University School of Medicine)
Elofsson, Arne (Department of Biochemistry and Biophysics and Science for Life Laboratory. Stockholm University. Box 1031)
Gobeill, Julien (Swiss Institute of Bioinformatics and HES-SO\HEG)
Foutel, Nicolás S. G. (Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biotecnológicas IIBIO. Universidad Nacional de San Martín)
Sudha, Govindarajan (Department of Biochemistry and Biophysics and Science for Life Laboratory. Stockholm University. Box 1031)
Guharoy, Mainak (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Horvath, Tamas (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Kajava, Andrey V. (Institut de Biologie Computationnelle(IBC))
Kovacs, Orsolya P. (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Lamb, John (Department of Biochemistry and Biophysics and Science for Life Laboratory. Stockholm University. Box 1031)
Lambrughi, Matteo (Computational Biology Laboratory. Danish Cancer Society Research Center)
Lazar, Tamas (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Leclercq, Jeremy Y. (Centre National de la Recherche Scientifique (França). Centre de Recherche en Biologie Cellulaire de Montpellier)
Leonardi, Emanuela (Fondazione Istituto di Ricerca Pediatrica (IRP). Città della Speranza)
Macedo-Ribeiro, Sandra (Instituto de Biologia Molecular e Celular (IBMC). Instituto de Investigação e Inovação em Saúde (i3S). Universidade Do Porto)
Macossay-Castillo, Mauricio (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Maiani, Emiliano (Computational Biology Laboratory. Danish Cancer Society Research Center)
Manso, José A. (Instituto de Biologia Molecular e Celular (IBMC). Instituto de Investigação e Inovação em Saúde (i3S). Universidade Do Porto)
Marino-Buslje, Cristina (Fundación Instituto Leloir (Buenos Aires, Argentina))
Martínez-Pérez, Elisabeth (Fundación Instituto Leloir (Buenos Aires, Argentina))
Mészáros, Bálint (MTA-ELTE Lendület Bioinformatics Research Group. Department of Biochemistry. Eötvös Loránd University)
Mičetić, Ivan (Department of Biomedical Sciences. University of Padova)
Minervini, Giovanni (Department of Biomedical Sciences. University of Padova)
Murvai, Nikoletta (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Necci, Marco (Department of Biomedical Sciences. University of Padova)
Ouzounis, Christos A. (Centre for Research and Technology Hellas (Tessalònica, Grècia))
Pajkos, Mátyás (MTA-ELTE Lendület Bioinformatics Research Group. Department of Biochemistry. Eötvös Loránd University)
Paladin, Lisanna (Department of Biomedical Sciences. University of Padova)
Pancsa, Rita (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Papaleo, Elena (Translational Disease Systems Biology. Faculty of Health and Medical Sciences. Novo Nordisk Foundation Center. Protein Research University of Copenhagen)
Parisi, Gustavo (Departamento de Ciencia y Tecnología. Universidad Nacional de Quilmes-CONICET)
Pasche, Emilie (Swiss Institute of Bioinformatics and HES-SO\HEG)
Barbosa Pereira, Pedro José (Instituto de Biologia Molecular e Celular (IBMC). Instituto de Investigação e Inovação em Saúde (i3S). Universidade Do Porto)
Promponas, Vasilis J. (Bioinformatics Research Laboratory. Department of Biological Sciences. University of Cyprus)
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Quaglia, Federica (Department of Biomedical Sciences. University of Padova)
Ruch, Patrick (Swiss Institute of Bioinformatics and HES-SO\HEG)
Salvatore, Marco (Department of Biochemistry and Biophysics and Science for Life Laboratory. Stockholm University. Box 1031)
Schad, Eva (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Szabo, Beata (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Szaniszló, Tamás (MTA-ELTE Lendület Bioinformatics Research Group. Department of Biochemistry. Eötvös Loránd University)
Tamana, Stella (Bioinformatics Research Laboratory. Department of Biological Sciences. University of Cyprus)
Tantos, Agnes (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Veljkovic, Nevena (Laboratory for Bioinformatics and Computational Chemistry. Institute of Nuclear Sciences Vinca. University of Belgrade)
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Vranken, Wim (Interuniversity Institute of Bioinformatics in Brussels (IB2). ULB-VUB)
Dosztányi, Zsuzsanna (MTA-ELTE Lendület Bioinformatics Research Group. Department of Biochemistry. Eötvös Loránd University)
Tompa, Peter (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Tosatto, Silvio (CNR Institute of Neurosceince)
Piovesan, Damiano (Department of Biomedical Sciences. University of Padova)

Fecha:	2020
Resumen:	The Database of Protein Disorder (DisProt, URL: https://disprot. org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.
Ayudas:	European Commission 778247 Ministerio de Economía y Competitividad BIO2016-78310-R
Nota:	Altres ajuts: European Regional Development Fund [POCI-01-0145-FEDER-031173, POCI-01-0145-FEDER-029221].- ICREA-Academia 2015
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Biological ontologies ; Data curation ; Databases, Protein ; Intrinsically disordered proteins ; Molecular sequence annotation
Publicado en:	Nucleic acids research, Vol. 48, issue D1 (Jan. 2020) , p. D269-D276, ISSN 1362-4962

DOI: 10.1093/nar/gkz975
PMID: 31713636

8 p, 674.6 KB

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