DisProt : intrinsic protein disorder annotation in 2020
Hatos, András (University of Padova. Department of Biomedical Sciences)
Hajdu-Soltész, Borbála (Eötvös Loránd University. Department of Biochemistry)
Monzon, Alexander M. (University of Padova. Department of Biomedical Sciences)
Palopoli, Nicolas (Departamento de Ciencia y Tecnología. Universidad Nacional de Quilmes-CONICET)
Álvarez, Lucía (Universidad Nacional de San Martín (Argentina))
Aykac-Fas, Burcu (Danish Cancer Society Research Center)
Bassot, Claudio (Stockholm University. Department of Biochemistry and Biophysics and Science for Life Laboratory)
Benítez, Guillermo I. (Universidad Nacional de Quilmes (Argentina). Departamento de Ciencia y Tecnología)
Bevilacqua, Martina (University of Padova. Department of Biomedical Sciences)
Chasapi, Anastasia (Centre for Research and Technology Hellas (Tessalònica, Grècia))
Chemes, Lucía Beatriz (Universidad de Buenos Aires. Departamento de Fisiología y Biología Molecular y Celular)
Davey, Norman E. (Institute of Cancer Research (Londres, Regne Unit))
Davidović, Radoslav (University of Belgrade. Laboratory for Bioinformatics and Computational Chemistry)
Dunker, A. Keith (Center for Computational Biology and Bioinformatics. Indiana University School of Medicine)
Elofsson, Arne (Stockholm University. Department of Biochemistry and Biophysics and Science for Life Laboratory)
Gobeill, Julien (Swiss Institute of Bioinformatics and HES-SO\HEG)
Foutel, Nicolás S. G. (Universidad Nacional de San Martín (Argentina))
Sudha, Govindarajan (Stockholm University. Department of Biochemistry and Biophysics and Science for Life Laboratory)
Guharoy, Mainak (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Horvath, Tamas (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Kajava, Andrey V. (Institut de Biologie Computationnelle (IBC))
Kovacs, Orsolya P. (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Lamb, John (Stockholm University. Department of Biochemistry and Biophysics and Science for Life Laboratory)
Lambrughi, Matteo (Danish Cancer Society Research Center)
Lazar, Tamas (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Leclercq, Jeremy Y. (Centre National de la Recherche Scientifique (França). Centre de Recherche en Biologie Cellulaire de Montpellier)
Leonardi, Emanuela (Fondazione Istituto di Ricerca Pediatrica (IRP). Città della Speranza)
Macedo-Ribeiro, Sandra (Instituto de Biologia Molecular e Celular (IBMC). Instituto de Investigação e Inovação em Saúde (i3S). Universidade Do Porto)
Macossay-Castillo, Mauricio (VIB-VUB Center for Structural Biology. Flanders Institute for Biotechnology (VIB))
Maiani, Emiliano (Danish Cancer Society Research Center)
Manso, José A. (Universidade do Porto. Instituto de Biologia Molecular e Celular)
Marino-Buslje, Cristina (Fundación Instituto Leloir (Buenos Aires, Argentina))
Martínez-Pérez, Elisabeth (Fundación Instituto Leloir (Buenos Aires, Argentina))
Mészáros, Bálint (Eötvös Loránd University. Department of Biochemistry)
Mičetić, Ivan (University of Padova. Department of Biomedical Sciences)
Minervini, Giovanni (University of Padova. Department of Biomedical Sciences)
Murvai, Nikoletta (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Necci, Marco (University of Padova. Department of Biomedical Sciences)
Ouzounis, Christos (Centre for Research and Technology Hellas (Tessalònica, Grècia))
Pajkos, Mátyás (Eötvös Loránd University. Department of Biochemistry)
Paladin, Lisanna (University of Padova. Department of Biomedical Sciences)
Pancsa, Rita (Hungarian Academy of Sciences. Institute of Enzymology)
Papaleo, Elena (University of Copenhagen)
Parisi, Gustavo (Universidad Nacional de Quilmes (Argentina). Departamento de Ciencia y Tecnología)
Pasche, Emilie (Swiss Institute of Bioinformatics and HES-SO\HEG)
Barbosa Pereira, Pedro José (Universidade do Porto. Instituto de Biologia Molecular e Celular)
Promponas, Vasilis J. (University of Cyprus. Department of Biological Sciences)
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Quaglia, Federica (Department of Biomedical Sciences. University of Padova)
Ruch, Patrick (Swiss Institute of Bioinformatics and HES-SO\HEG)
Salvatore, Marco (Stockholm University. Department of Biochemistry and Biophysics and Science for Life Laboratory)
Schad, Eva (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Szabo, Beata (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Szaniszló, Tamás (Eötvös Loránd University. Department of Biochemistry)
Tamana, Stella (University of Cyprus. Department of Biological Sciences)
Tantos, Agnes (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Veljkovic, Nevena (University of Belgrade. Institute of Nuclear Sciences Vinca)
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Vranken, Wim (Interuniversity Institute of Bioinformatics in Brussels (IB2). ULB-VUB)
Dosztányi, Zsuzsanna (Eötvös Loránd University. Department of Biochemistry.)
Tompa, Peter (Institute of Enzymology. Research Centre for Natural Sciences. Hungarian Academy of Sciences)
Tosatto, Silvio (CNR Institute of Neuroscience)
Piovesan, Damiano (University of Padova. Department of Biomedical Sciences)

Data:	2020
Resum:	The Database of Protein Disorder (DisProt, URL: https://disprot. org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.
Ajuts:	European Commission 778247 Agencia Estatal de Investigación BIO2016-78310-R
Nota:	Altres ajuts: European Regional Development Fund [POCI-01-0145-FEDER-031173, POCI-01-0145-FEDER-029221].- ICREA-Academia 2015
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biological ontologies ; Data curation ; Databases, Protein ; Intrinsically disordered proteins ; Molecular sequence annotation
Publicat a:	Nucleic acids research, Vol. 48, issue D1 (Jan. 2020) , p. D269-D276, ISSN 0305-1048

DOI: 10.1093/nar/gkz975
PMID: 31713636

8 p, 674.6 KB

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