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Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron : The Myocardial- Trial
Núñez, Julio (Universitat Jaume I)
Miñana, Gema (Universitat Jaume I)
Cardells, Ingrid (Hospital Clínic Universitari (València))
Palau, Patricia (Universitat Jaume I. Hospital General de Castellón)
Llàcer, Pau (Hospital de Manises (València))
Fácila, Lorenzo (Hospital General Universitario de Valencia)
Almenar Bonet, Luis (Hospital Universitari i Politècnic La Fe (València))
López-Lereu, Maria P. (Hospital Clínic Universitari (València))
Monmeneu, Jose V. (Hospital Clínic Universitari (València))
Amiguet, Martina (Hospital Clínic Universitari (València))
González, Jessika (Hospital Clínic Universitari (València))
Serrano, Alicia (Consorci Hospitalari Provincial de Castelló)
Montagud, Vicente (Hospital General Universitario de Valencia)
López-Vilella, Raquel (Hospital Universitari i Politècnic La Fe (València))
Valero, Ernesto (Universitat Jaume I)
García-Blas, Sergio (Universitat Jaume I)
Bodi, Vicente (Universitat Jaume I)
De la Espriella, Rafael (Hospital Clínic Universitari (València))
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro, Jorge (Universitat de València)
Górriz, José Luis (Universitat de València)
Sanchis, Juan (Universitat Jaume I)
Chorro, Francisco J. (Universitat Jaume I)
Comín-Colet, Josep (Institut Hospital del Mar d'Investigacions Mèdiques)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date: 2020
Abstract: Intravenous ferric carboxymaltose () improves symptoms, functional capacity, and quality of life in heart failure and iron deficiency. The mechanisms underlying these effects are not fully understood. The aim of this study was to examine changes in myocardial iron content after administration in patients with heart failure and iron deficiency using cardiac magnetic resonance. Fifty-three stable heart failure and iron deficiency patients were randomly assigned 1:1 to receive intravenous or placebo in a multicenter, double-blind study. T2* and T1 mapping cardiac magnetic resonance sequences, noninvasive surrogates of intramyocardial iron, were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. Results are presented as least-square means with 95% CI. The primary end point was the change in T2* and T1 mapping at 7 and 30 days. Median age was 73 (65-78) years, with N-terminal pro-B-type natriuretic peptide, ferritin, and transferrin saturation medians of 1690 pg/mL (1010-2828), 63 ng/mL (22-114), and 15. 7% (11. 0-19. 2), respectively. Baseline T2* and T1 mapping values did not significantly differ across treatment arms. On day 7, both T2* and T1 mapping (ms) were significantly lower in the arm (36. 6 [34. 6-38. 7] versus 40 [38-42. 1], P =0. 025; 1061 [1051-1072] versus 1085 [1074-1095], P =0. 001, respectively). A similar reduction was found at 30 days for T2* (36. 3 [34. 1-38. 5] versus 41. 1 [38. 9-43. 4], P =0. 003), but not for T1 mapping (1075 [1065-1085] versus 1079 [1069-1089], P =0. 577). In patients with heart failure and iron deficiency, administration was associated with changes in the T2* and T1 mapping cardiac magnetic resonance sequences, indicative of myocardial iron repletion. : . Unique identifier: 03398681.
Grants: Instituto de Salud Carlos III 16-11-00420
Instituto de Salud Carlos III 16-11-00403
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Cardiac magnetic resonance ; Ferric carboxymaltose ; Heart failure ; Iron deficiency ; Myocardial iron
Published in: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 9 (february 2020) , ISSN 2047-9980

DOI: 10.1161/JAHA.119.014254
PMID: 32067585


17 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2020-07-06, last modified 2023-09-29



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