First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques
Corsetti, Maura (University of Nottingham. Nottingham Digestive Diseases Centre)
Costa, Marcello (Flinders University. Human Physiology and Centre of Neuroscience)
Bassotti, Gabrio (University of Perugia Medical School. Department of Medicine)
Bharucha, Adil E. (Mayo Clinic. Division of Gastroenterology and Hepatology)
Borrelli, Osvaldo (Great Ormond Street Hospital for Children (Londres))
Dinning, Phil (Flinders Medical Centre. Department of Gastroenterology and Surgery)
Di Lorenzo, Carlo (The Ohio State University. Department of Pediatric Gastroenterology)
Huizinga, Jan D. (McMaster University. Department of Medicine)
Jiménez Farrerons, Marcel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Rao, Satish (Augusta University. Division of Gastroenterology/Hepatology)
Spiller, Robin (University of Nottingham. Nottingham Digestive Diseases Centre)
Spencer, Nick J. (Flinders University. Discipline of Human Physiology)
Lentle, Roger (Massey University. Digestive Biomechanics Group)
Pannemans, Jasper (Emma Children's Hospital/Academic Medical Centre. Department of Paediatric Gastroenterology and Nutrition)
Thys, Alexander (Emma Children's Hospital/Academic Medical Centre. Department of Paediatric Gastroenterology and Nutrition)
Benninga, Marc (University of Leuven. Translational Research Center for Gastrointestinal disorders (TARGID))
Tack, Jan (Emma Children's Hospital/Academic Medical Centre. Department of Paediatric Gastroenterology and Nutrition)

Data:	2019
Resum:	Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminologies and definitions have been used to describe colonic motor patterns in children, adults and animals. An example is the distinction between the high-amplitude propagating contractions in humans and giant contractions in animals. Harmonized terminology and definitions are required that are applicable to the study of colonic motility performed by basic scientists and clinicians, as well as adult and paediatric gastroenterologists. As clinical studies increasingly require adequate animal models to develop and test new therapies, there is a need for rational use of terminology to describe those motor patterns that are equivalent between animals and humans. This Consensus Statement provides the first harmonized interpretation of commonly used terminology to describe colonic motor function and delineates possible similarities between motor patterns observed in animal models and humans in vitro (ex vivo) and in vivo. The consolidated terminology can be an impetus for new research that will considerably improve our understanding of colonic motor function and will facilitate the development and testing of new therapies for colonic motility disorders. This Consensus Statement provides a conceptual and methodological framework to expand research on colonic motility in experimental animals and humans. The work is intended to facilitate the development of new drugs for common colonic motility disorders and of appropriate diagnostic and therapeutic algorithms for the management of paediatric and adult patients.
Nota:	Altres ajuts: NIDDK/R01DK78924
Nota:	Altres ajuts: NIDDK/5R21DK104127-02 and U-34
Nota:	Altres ajuts: NIDDK/1434-DK109191-01
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gastrointestinal system ; Enteric nervous system ; Gastrointestinal models
Publicat a:	Nature reviews, Vol. 16 (july 2019) , p. 559-579, ISSN 1759-5053

DOI: 10.1038/s41575-019-0167-1
PMID: 31296967

21 p, 4.3 MB

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