Continuous Theta-Burst Stimulation in Children With High-Functioning Autism Spectrum Disorder and Typically Developing Children
Jannati, Ali (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School)
Block, Gabrielle (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School)
Ryan, Mary A. (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School)
Kaye, Harper L. (Harvard Medical School)
Kayarian, Fae B. (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School)
Bashir, Shahid (Neuroscience Center, King Fahad Specialist Hospital Dammam)
Oberman, Lindsay M. (Neuroplasticity and Autism Spectrum Disorder Program, Department of Psychiatry and Human Behavior, E. P. Bradley Hospital, Warren Alpert Medical School, Brown University)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Rotenberg, Alexander (Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Objectives : A neurophysiologic biomarker for autism spectrum disorder (ASD) is highly desirable and can improve diagnosis, monitoring, and assessment of therapeutic response among children with ASD. We investigated the utility of continuous theta-burst stimulation (cTBS) applied to the motor cortex (M1) as a biomarker for children and adolescents with high-functioning (HF) ASD compared to their age- and gender-matched typically developing (TD) controls. We also compared the developmental trajectory of long-term depression- (LTD-) like plasticity in the two groups. Finally, we explored the influence of a common brain-derived neurotrophic factor (BDNF) polymorphism on cTBS aftereffects in a subset of the ASD group. Methods : Twenty-nine children and adolescents (age range 10-16) in ASD (n = 11) and TD (n = 18) groups underwent M1 cTBS. Changes in MEP amplitude at 5-60 min post-cTBS and their cumulative measures in each group were calculated. We also assessed the relationship between age and maximum cTBS-induced MEP suppression (ΔMEP) in each group. Finally, we compared cTBS aftereffects in BDNF Val/Val (n = 4) and Val/Met (n = 4) ASD participants. Results : Cumulative cTBS aftereffects were significantly more facilitatory in the ASD group than in the TD group (P 's < 0. 03). ΔMEP was negatively correlated with age in the ASD group (r = −0. 67, P = 0. 025), but not in the TD group (r = −0. 12, P = 0. 65). Cumulative cTBS aftereffects were not significantly different between the two BDNF subgroups (P -values > 0. 18). Conclusions : The results support the utility of cTBS measures of cortical plasticity as a biomarker for children and adolescents with HF-ASD and an aberrant developmental trajectory of LTD-like plasticity in ASD.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Transcranial magnetic stimulation ; Continuous theta-burst stimulation ; Plasticity ; Biomarker ; Autism spectrum disorder ; BDNF
Publicat a:	Frontiers in Integrative Neuroscience, Vol. 14 (march 2020) , ISSN 1662-5145

DOI: 10.3389/fnint.2020.00013
PMID: 32231523

14 p, 2.2 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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