Inference of natural selection from ancient DNA
Dehasque, Marianne (Stockholm University)
Ávila-Arcos, Maria C. (Universidad Nacional Autónoma de México Juriquilla)
Díez, David (Stockholm University)
Fumagalli, Matteo (Imperial College London)
Guschanski, Katerina (Uppsala University)
Lorenzen, Eline (University of Copenhagen)
Malaspinas, Anna-Sapfo (University of Lausanne. SIB Swiss Institute of Bioinformatics)
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Martin, Michael (Norwegian University of Science and Technology)
Murray, Gemma G. R. (University of Cambridge)
Papadopulos, Alexander S. T. (Bangor University)
Therkildsen, Nina Overgaard (Cornell University)
Wegmann, Daniel (Swiss Institute of Bioinformatics)
Dalén, Love (Swedish Museum of Natural History)
Foote, Andrew D. (Bangor University)

Data:	2020
Resum:	Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct quantification of population parameters collected before, during, and after genetic changes driven by selection. In this Comment and Opinion, we advocate for the inclusion of temporal sampling and the generation of paleogenomic datasets in evolutionary biology, and highlight some of the recent advances that have yet to be broadly applied by evolutionary biologists. In doing so, we consider the expected signatures of balancing, purifying, and positive selection in time series data, and detail how this can advance our understanding of the chronology and tempo of genomic change driven by selection. However, we also recognize the limitations of such data, which can suffer from postmortem damage, fragmentation, low coverage, and typically low sample size. We therefore highlight the many assumptions and considerations associated with analyzing paleogenomic data and the assumptions associated with analytical methods.
Ajuts:	European Commission 663830
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adaptation ; Ancient DNA ; Natural selection ; Paleogenomics ; Time series
Publicat a:	Evolution Letters, Vol. 4, Issue 2 (April 2020) , p. 94-108, ISSN 2056-3744

DOI: 10.1002/evl3.165
PMID: 32313686

15 p, 726.6 KB

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