Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease : Lights and Shadows
Xicoy, Helena (Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, 6525 GA Nijmegen, The Netherlands)
Peñuelas, Núria (Hospital Universitari Vall d'Hebron)
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Laguna, Ariadna (Hospital Universitari Vall d'Hebron)

Data:	2019
Resum:	Parkinson's disease (PD) is a neurodegenerative disorder that currently affects 1% of the population over the age of 60 years, for which no disease-modifying treatments exist. This lack of effective treatments is related to the advanced stage of neurodegeneration existing at the time of diagnosis. Thus, the identification of early stage biomarkers is crucial. Biomarker discovery is often guided by the underlying molecular mechanisms leading to the pathology. One of the central pathways deregulated during PD, supported both by genetic and functional studies, is the autophagy-lysosomal pathway. Hence, this review presents different studies on the expression and activity of autophagic and lysosomal proteins, and their functional consequences, performed in peripheral human biospecimens. Although most biomarkers are inconsistent between studies, some of them, namely HSC70 levels in sporadic PD patients, and cathepsin D levels and glucocerebrosidase activity in PD patients carrying GBA mutations, seem to be consistent. Hence, evidence exists that the impairment of the autophagy-lysosomal pathway underlying PD pathophysiology can be detected in peripheral biosamples and further tested as potential biomarkers. However, longitudinal, stratified, and standardized analyses are needed to confirm their clinical validity and utility.
Ajuts:	Ministerio de Economía y Competitividad SAF2015-73997-JIN Ministerio de Economía y Competitividad AF2016-77541-R Ministerio de Economía y Competitividad SAF2015-73997-JI
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Parkinson's disease ; Biomarker ; Autophagy ; Lysosome ; Glucocerebrosidase ; Alpha synuclein
Publicat a:	Cells, Vol. 8 (october 2019) , ISSN 2073-4409

DOI: 10.3390/cells8111317
PMID: 31731485

20 p, 1.6 MB

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