Web of Science: 200 cites, Scopus: 217 cites, Google Scholar: cites,
Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials
Ibanez, Borja (Hospital Universitario Fundación Jiménez Díaz)
Aletras, Anthony H. (Skåne University Hospital (Suècia))
Arai, Andrew E. (National Heart, Lung, and Blood Institute (Bethesda, Estats Units d'Amèrica))
Arheden, Hakan (Skåne University Hospital (Suècia))
Bax, Jeroen (Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Leiden, the Netherlands)
Berry, Colin (University of Glasgow. Glasgow Cardiovascular Research Centre)
Bucciarelli-Ducci, Chiara (University of Bristol. Bristol Heart Institute)
Croisille, Pierre (University Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint-Etienne, France)
Dall'Armellina, Erica (Leeds Institute of Cardiovascular and Metabolic Medicine, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom)
Dharmakumar, Rohan (Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, and Division of Cardiology, Department of Medicine, University of California, Los Angeles, California)
Eitel, Ingo (University Heart Center Lübeck, Medical Clinic II (Cardiology/ Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany)
Fernández-Jiménez, Rodrigo (Cardiology Department, Icahn School of Medicine at Mount Sinai, New York, New York)
Friedrich, Matthias G. (Department of Medicine, Heidelberg University, Heidelberg, Germany)
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hausenloy, Derek J. (Tecnologico de Monterrey, Centro de Biotecnologia-FEMSA, Nuevo Leon, Mexico)
Kim, Raymond J. (Duke Cardiovascular Magnetic Resonance Center, Division of Cardiology, and Department of Radiology, Duke University Medical Center, Durham, North Carolina)
Kozerke, Sebastian (Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland)
Kramer, Christopher M. (Departments of Medicine and Radiology, University of Virginia Health System, Charlottesville, Virginia)
Salerno, Michael (Departments of Medicine and Radiology, University of Virginia Health System, Charlottesville, Virginia; and)
Sánchez-González, Javier (Philips Healthcare, Madrid, Spain)
Sanz, Javier (Cardiology Department, Icahn School of Medicine at Mount Sinai, New York, New York)
Fuster, Valentín (Cardiology Department, Icahn School of Medicine at Mount Sinai, New York, New York)
Universitat Autònoma de Barcelona

Data: 2019
Resum: After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.
Nota: Altres ajuts: The CNIC is supported by the ISCiii, MICINN, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (award SEV-2015-0505). This research was supported (in part) by the Intramural Research Program of the National Institutes of Health, National Heart, Lung, and Blood Institute. Agencies supporting the research of coauthors are acknowledged in the Online Appendix. The authors appreciate the scientific commitment of the sponsor unrelated to industrial interests. Dr. Arai has a U.S. Government Cooperative Research and Development Agreement with Siements; has a U.S. Government Cooperative Research and Development Agreement (Clinical Trial Agreement) with Bayer; and has a U.S. Government official duty (unpaid consultant) with Circle CVI (licensed software developed at the National Institutes of Health). Dr. Arheden is a shareholder in Imacor AB. Dr. Bax has received speaker fees from Abbott Vascular and Boehringer Ingelheim; and his institution has received unrestricted research grants from Medtronic, Boston Scientific, Biotronik, Edwards Lifesciences, and GE Healthcare. Dr. Berry has institutional agreements between the University of Glasgow (employer) and Abbott Vascular, AstraZeneca, Coroventis, DalCor, GlaxoSmithKline, HeartFlow, Novartis, Philips, and Siemens Healthcare. Dr. Bucciarelli-Ducci has served as a consultant for Circle Cardiovascular Imaging. Dr. Dharmakumar has a research agreement with Siemens Healthcare. Dr. Friedrich has served as a board member and advisor for Circle Cardiovascular Imaging. Dr. Kim has received an educational grant from Siemens Healthineers; and is cofounder of HeartIT LLC. Dr. Salerno has received research support from Siemens Healthineers. Dr Croisille's institution holds a research agreement with Siemens Healthcare, Circle Cardiovascular Imaging, and Olea Medical. Dr. Sánchez-González is an employee of Philips.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Area at risk ; Clinical trial ; Edema ; Endpoint ; Infarct size ; Magnetic resonance imaging ; Myocardial infarction ; STEMI
Publicat a: Journal of the American College of Cardiology, Vol. 74 (july 2019) , p. 238-256, ISSN 1558-3597

DOI: 10.1016/j.jacc.2019.05.024
PMID: 31296297


33 p, 1.7 MB

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 Registre creat el 2020-07-28, darrera modificació el 2023-03-02



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