Vaccination Against Porcine Circovirus-2 Reduces Severity of Tuberculosis in Wild Boar
Risco, David (Innovación en Gestión y Conservación de Ungulados S.L.)
Bravo, María (Universidad de Extremadura. Departamento de Sanidad Animal)
Martínez, Remigio (Universidad de Extremadura. Departamento de Sanidad Animal)
Torres, Almudena (Universidad de Extremadura. Departamento de Sanidad Animal)
Gonçalves, Pilar (Innovación en Gestión y Conservación de Ungulados S.L.)
Cuesta, Jesús M. (Universidad de Extremadura. Departamento de Medicina Animal)
García-Jiménez, Waldo Luis (University of Surrey. Department of Pathology and Infectious Diseases)
Cerrato, Rosario (Innovación en Gestión y Conservación de Ungulados S.L.)
Iglesias, Rocío (Universidad de Extremadura. Departamento de Bioquímica y Biología Molecular y Genética)
Galapero, Javier (Universidad de Extremadura. Departamento de Medicina Animal)
Serrano Ferron, Emmanuel (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Gómez, Luis (Universidad de Extremadura. Departamento de Medicina Animal)
Fernández-Llario, Pedro (Innovación en Gestión y Conservación de Ungulados S.L.)
Hermoso de Mendoza, Javier (Universidad de Extremadura. Departamento de Sanidad Animal)

Data:	2018
Resum:	Tuberculosis (TB) in wild boar (Sus scrofa) may be affected by coinfections with other pathogens, such as porcine circovirus type 2 (PCV2). Therefore, sanitary measures focused on controlling PCV2 could be useful in reducing the impact of TB in this wild suid. The aim of this study was to explore whether vaccination against PCV2 targeting young animals affects TB prevalence and TB severity in wild boar. The study was conducted on a game estate in mid-western Spain. Seventy animals of ages ranging from 4 to 8 months were captured, individually identified, vaccinated against PCV2 and released, forming a vaccinated group. Not-captured animals cohabiting with the vaccinated wild boar constituted the control group. Animals from both groups were hunted between 2013 and 2016 and a TB diagnosis based on pathological assessment and microbiological culture was made in all of them. The effect of PCV2 vaccination on TB prevalence and severity was explored using generalized lineal models. Whereas TB prevalence was similar in vaccinated and control groups (54. 55 vs. 57. 78%), vaccinated animals showed less probabilities to develop generalized TB lesions. Furthermore, mean TB severity score was significantly lower in vaccinated animals (1. 55 vs. 2. 42) suggesting a positive effect of PCV2 vaccination.
Ajuts:	Ministerio de Economía y Competitividad PTQ14-06663 Ministerio de Economía y Competitividad RYC-2016-21120
Nota:	Dr. D. Risco was supported by a Torres Quevedo Grant of the Ministerio de Economía y Competitividad of Spain (PTQ14-06663 and RYC-2016-21120) and by the postdoctoral programme of the Gobierno de Extremadura (Ref PO14024). E. Serrano was funded by the Spanish Ministerio de Economia y Competitividad (MINECO) through a Ramon y Cajal agreement (RYC-2016-21120).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Senglars ; Porcs ; Malalties ; Vacunació d'animals ; Epidemiologia veterinària
Publicat a:	Ecohealth, Vol. 15 (2018) , p. 388-395, ISSN 1612-9210

DOI: 10.1007/s10393-018-1321-x

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