Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells
Marcelo, Gonçalo A. (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Oliveira, Elisabete (PROTEOMASS Scientific Society)

Date:	2020
Abstract:	Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5. 0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.
Grants:	Ministerio de Ciencia e Innovación RTI2018-098027-B-C21 Ministerio de Ciencia e Innovación RTI2018-088027-B-C22 Ministerio de Economía y Competitividad SEV-2017-0706
Note:	Altres ajuts: F.N. thanks to COST Action CA17121. F.N. and J.L. thanks to COST Action CA15138.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Luminescence ; Silicon quantum dots ; Mesoporous silica nanoparticles ; Drug delivery ; Colorectal cancer cells ; Doxorubicin
Published in:	Dyes and pigments, Vol. 181 (Oct. 2020) , art. 108393, ISSN 1873-3743

DOI: 10.1016/j.dyepig.2020.108393

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles