Differential DNA methylation of vocal and facial anatomy genes in modern humans
Gokhman, David (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))
Nissim-Rafinia, Malka (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))
Agranat-Tamir, Lily (The Hebrew University of Jerusalem. Department of Statistics (Israel))
Housman, Genevieve (Arizona State University. Center for Evolution and Medicine (USA))
García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Lizano, Esther (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Cheronet, Olivia (University of Vienna. Department of Evolutionary Anthropology (Austria))
Mallick, Swapan (Howard Hughes Medical Institute. Harvard Medical School (USA))
Nieves-Colón, Maria A. (Arizona State University. Center for Evolution and Medicine (USA))
Li, Heng (Broad Institute of MIT and Harvard)
Alpaslan-Roodenberg, Songül (Harvard Medical School. Department of Genetics (USA))
Novak, Mario (University College Dublin. Earth Institute and School of Archaeology (Ireland))
Gu, Hongcang (Broad Institute of MIT and Harvard)
Osinski, Jason M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA))
Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Gelabert, Pere (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Lipende, Iddi (Jane Goodall Institute. Gombe Stream Research Center (Tanzania))
Mjungu, Deus (Jane Goodall Institute. Gombe Stream Research Center (Tanzania))
Kondova, Ivanela (Biomedical Primate Research Centre (Netherlands))
Bontrop, Ronald (Biomedical Primate Research Centre (Netherlands))
Kullmer, Ottmar (Senckenberg Center of Human Evolution and Paleoecology. Department of Palaeoanthropology and Messel Research (Germany))
Weber, Gerhard (University of Vienna. Department of Evolutionary Anthropology (Austria))
Shahar, Tal (Shaare Zedek Medical Center. Department of Neurosurgery (Israel))
Dvir-Ginzberg, Mona (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Cartilage Biology (Israel))
Faerman, Marina (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Bioanthropology and Ancient DNA (Israel))
Quillen, Ellen E. (Texas Biomedical Research Institute. Department of Genetics (USA))
Meissner, Alexander (Harvard University. Department of Stem Cell and Regenerative Biology (USA))
Lahav, Yonatan (The Hebrew University Medical School (Israel))
Kandel, Leonid (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel))
Liebergall, Meir (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel))
Prada, María E. (I.E.S.O. 'Los Salados'. Junta de Castilla y León)
Vidal, Julio M. (Junta de Castilla y León. Servicio de Cultura de León)
Gronostajski, Richard M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA))
Stone, Anne C. (Arizona State University. Institute of Human Origins)
Yakir, Benjamin (The Hebrew University of Jerusalem. Department of Statistics (Israel))
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Pinhasi, Ron (University of Vienna. Department of Evolutionary Anthropology (Austria))
Reich, David (Howard Hughes Medical Institute. Harvard Medical School (USA))
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Meshorer, Eran (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences (Israel))
Carmel, Liran (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))

Date:	2020
Abstract:	Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract.
Grants:	Ministerio de Economía y Competitividad BFU2017-86471-P Ministerio de Economía y Competitividad BFU2015-64699-P European Commission 263441
Note:	Altres ajuts: Obra Social "La Caixa" i CERCA Programme/Generalitat de Catalunya
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adult ; Aged ; Animals ; Cells Cultured ; Child ; Chondrocytes ; DNA Methylation ; DNA Ancient ; Evolution Molecular ; Face ; Female ; Gene Regulatory Networks ; Genetic Speciation ; Humans ; Larynx ; Male ; Middle Aged ; Neanderthals ; Pan troglodytes ; Phenotype ; Phonation ; Primary Cell Culture ; Tongue ; Vocal Cords ; Vocalization Animal
Published in:	Nature communications, Vol. 11 (March 2020) , art. 1189, ISSN 2041-1723

DOI: 10.1038/s41467-020-15020-6
PMID: 32132541

21 p, 2.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut Català de Paleontologia Miquel Crusafont (ICP)
Articles > Research articles
Articles > Published articles