![]() |
|||||||||||||||
![]() |
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > Comparison of plasma lipoprotein composition and function in cerebral amyloid angiopathy and Alzheimer's disease |
Data: | 2021 |
Resum: | Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation. |
Ajuts: | Instituto de Salud Carlos III PI13-00364 Instituto de Salud Carlos III PI16-00471 Instituto de Salud Carlos III PI14-01134 Instituto de Salud Carlos III PI17-00275 Instituto de Salud Carlos III FI17-00031 Instituto de Salud Carlos III RD16-0019-0021 Instituto de Salud Carlos III CPII17-00010 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1149 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Cerebral amyloid angiopathy ; Alzheimer's disease ; Lipoprotein composition ; Lipid profile ; Apolipoproteins |
Publicat a: | Biomedicines, Vol. 9 Núm. 1 (2021) , p. 72, ISSN 2227-9059 |
14 p, 488.9 KB |