Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era
Porta-Pardo, Eduard. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Valencia, A. (Institució Catalana de Recerca i Estudis Avançats)
Godzik, A. (Division of Biomedical Sciences. University of California Riverside School of Medicine)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	One of the key challenges of cancer biology is to catalogue and understand the somatic genomic alterations leading to cancer. Although alternative definitions and search methods have been developed to identify cancer driver genes and mutations, analyses of thousands of cancer genomes return a remarkably similar catalogue of around 300 genes that are mutated in at least one cancer type. Yet, many features of these genes and their role in cancer remain unclear, first and foremost when a somatic mutation is truly oncogenic. In this review, we first summarize some of the recent efforts in completing the catalogue of cancer driver genes. Then, we give an overview of different aspects that influence the oncogenicity of somatic mutations in the core cancer driver genes, including their interactions with the germline genome, other cancer driver mutations, the immune system, or their potential role in healthy tissues. In the coming years, this research holds promise to illuminate how, when, and why cancer driver genes and mutations are really drivers, and thereby move personalized cancer medicine and targeted therapies forward.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca LCF-BQ-PI18-11630003
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Subject:	Cancer drivers ; Cancer genes ; Multiscale analysis ; Personalized medicine ; Variants of unknown significance
Published in:	FEBS Letters, Vol. 594 Núm. 24 (december 2020) , p. 4233-4246, ISSN 1873-3468

DOI: 10.1002/1873-3468.13781
PMID: 32239503

14 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Published articles