GH/IGF-1 Abnormalities and Muscle Impairment : from basic research to clinical practice
Biagetti, Betina (Hospital Universitari Vall d'Hebron)
Simó Canonge, Rafael (Vall d'Hebron Institut de Recerca (VHIR))

Data:	2021
Resum:	The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients' poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acromegaly ; Myopathy ; Review ; Growth hormone ; IGF-1
Publicat a:	International journal of molecular sciences, Vol. 22 Núm. 1 (2021) , p. 415, ISSN 1422-0067

DOI: 10.3390/ijms22010415
PMID: 33401779

18 p, 2.2 MB

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