Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
Sánchez, Juan Pablo (Institut de Recerca i Tecnologia Agroalimentàries)
Legarra, Andres (National Institute for Agronomic Research)
Velasco-Galilea, M. (Institut de Recerca i Tecnologia Agroalimentàries)
Piles, M. (Institut de Recerca i Tecnologia Agroalimentàries)
Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica)
Rafel Guarro, Oriol (Institut de Recerca i Tecnologia Agroalimentàries)
González-Rodríguez, Olga (Institut de Recerca i Tecnologia Agroalimentàries)
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries)

Fecha:	2020
Resumen:	Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two-trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non-genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome-wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits.
Ayudas:	European Commission 63353 Ministerio de Ciencia e Innovación RTA2014-00015-C2-01 Ministerio de Economía y Competitividad RTA2011-00064-00-00 Ministerio de Economía y Competitividad RTI2018-097610-R-I00 Ministerio de Economía y Competitividad RYC/2013-12573
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Candidate gene ; Feed efficiency ; Genome-wide association study ; Growth ; Pooled records ; Rabbit ; Restricted feeding
Publicado en:	Animal Genetics, Vol. 51, Issue 5 (October 2020) , p. 799-810, ISSN 1365-2052

DOI: 10.1111/age.12988
PMID: 32697387

12 p, 878.0 KB

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