| Resum: |
The association of pulmonary congestion assessed by lung ultrasound (LUS) and biomarkers-other than N-terminal pro-brain natriuretic peptide (NT-proBNP)-is uncertain. We investigated the relationship between total B-line count by LUS and several biomarkers in outpatients with suspicion of heart failure (HF). Primary care patients with suspected new-onset nonacute HF were evaluated both with a 12-scan LUS protocol (8 anterolateral areas plus 4 lower posterior thoracic areas) and 11 inflammatory and cardiovascular biomarkers. A cardiologist blinded to LUS and biomarkers except NT-proBNP confirmed HF diagnosis. After log-transformation of biomarkers' concentrations, unadjusted and adjusted correlations were performed. A total of 170 patients were included (age 76 ± 10 years, 67. 6% women). HF diagnosis was confirmed in 38 (22. 4%) patients. After adjustment by age, sex, body mass index, and renal function, total B-line sum significantly correlated with NT-proBNP (R = 0. 29, p < 0. 001), growth/differentiation factor-15 (GDF-15; R = 0. 23, p = 0. 003), high-sensitive Troponin T (hsTnT; R = 0. 36, p < 0. 001), soluble interleukin-1 receptor-like 1 (sST2; R = 0. 29, p < 0. 001), cancer antigen 125 (CA-125; R = 0. 17, p = 0. 03), high-sensitivity C-reactive protein (hsCRP; R = 0. 20, p = 0. 009), and interleukin (IL)-6 (R = 0. 23, p = 0. 003). In contrast, IL-33 (R = -0. 01, p = 0. 93), IL-1β (R = -0. 10, p = 0. 20), soluble neprilysin (sNEP; R = 0. 09, p = 0. 24), tumor necrosis factor-alpha (TNF-α; R = 0. 07, p = 0. 39), and TNF-α receptor superfamily member 1A (TNFRSF1A; R = 0. 14, p = 0. 07) did not. Total B-line sum correlated significantly, although moderately, with congestion and several inflammation biomarkers. Unexpectedly, the highest correlation found was with hsTnT. |
visitant ::
identificació
(Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina)
