Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity
Ramon-Krauel, Marta (Institut de Recerca Sant Joan de Déu)
Leal-Witt, María Jesús (Institut de Recerca Sant Joan de Déu)
Osorio-Conles, Óscar (Institut de Recerca Sant Joan de Déu)
Amat-Bou, Montse (Institut de Recerca Sant Joan de Déu)
Lerin, Carles (Institut de Recerca Sant Joan de Déu)
Martínez Selva, David (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, adiponectin, and SHBG are present in prepubertal children. We determined several morphometric and biochemical parameters in normal-weight (n =15) and obese prepubertal (n =51) children, as well as quantified plasma SHBG, TNFα receptor 1 (TNFα-R1), and adiponectin levels. Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0. 05) with TNFα (negatively, ßstd= - 0. 31) and adiponectin (positively, ßstd= 0. 58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children. Our results suggest that plasma adiponectin levels may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.
Ajuts:	Instituto de Salud Carlos III PI12-01357
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Prepubertal children ; Obesity ; Sex hormone-binding globulin ; Cytokines
Publicat a:	Molecular and Cellular Pediatrics, Vol. 8 (march 2021) , ISSN 2194-7791

DOI: 10.1186/s40348-021-00113-z
PMID: 33689083

6 p, 431.4 KB

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