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COVID-19 in patients with autoimmune diseases : characteristics and outcomes in a multinational network of cohorts across three countries
Tan, Eng Hooi (University of Oxford. Centre for Statistics in Medicine)
Sena, Anthony G. (Erasmus University Medical Center)
Prats-Uribe, Albert (University of Oxford. Centre for Statistics in Medicine)
You, Seng Chan (Suwon)
Ahmed, Waheed-Ul-Rahman (University of Exeter)
Kostka, Kristin (Real World Solutions) [...] Mostra tots els 47 autors

Data: 2021
Resum: Patients with autoimmune diseases were advised to shield to avoid COVID-19, but information on their prognosis is lacking. We characterised 30-day outcomes and mortality after hospitalisation with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza. A multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center (CUIMC) (United States [US]), Optum [US], Department of Veterans Affairs (VA) (US), Information System for Research in Primary Care-Hospitalisation Linked Data (SIDIAP-H) (Spain), and claims data from IQVIA Open Claims (US) and Health Insurance and Review Assessment (HIRA) (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalised between January and June 2020 with COVID-19, and similar patients hospitalised with influenza in 2017-2018 were included. Outcomes were death and complications within 30 days of hospitalisation. We studied 133 589 patients diagnosed and 48 418 hospitalised with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged ≥50 years with previous comorbidities. The prevalence of hypertension (45. 5-93. 2%), chronic kidney disease (14. 0-52. 7%) and heart disease (29. 0-83. 8%) was higher in hospitalised vs diagnosed patients with COVID-19. Compared with 70 660 hospitalised with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2. 2% to 4. 3% vs 6. 3% to 24. 6%). Compared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: COVID-19 ; Autoimmune condition ; Mortality ; Hospitalisation ; Open science ; Observational Health Data Sciences and Informatics (OHDSI) ; Observational Medical Outcomes Partnership (OMOP)
Publicat a: Rheumatology, march 2021, ISSN 1462-0332

DOI: 10.1093/rheumatology/keab250
PMID: 33725121


28 p, 649.1 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2021-04-05, darrera modificació el 2025-03-31



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