AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins
Ramos-Vicente, David (Institut d'Investigació Biomèdica Sant Pau)
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	In mammalian synapses, the function of ionotropic glutamate receptors is critically modulated by auxiliary subunits. Most of these specifically regulate the synaptic localization and electrophysiological properties of AMPA-type glutamate receptors (AMPARs). Here, we comprehensively investigated the animal evolution of the protein families that contain AMPAR auxiliary subunits (ARASs). We observed that, on average, vertebrates have four times more ARASs than other animal species. We also demonstrated that ARASs belong to four unrelated protein families: CACNG-GSG1, cornichon, shisa and Dispanin C. Our study demonstrates that, despite the ancient origin of these four protein families, the majority of ARASs emerged during vertebrate evolution by independent but convergent processes of neo/subfunctionalization that resulted in the multiple ARASs found in present vertebrate genomes. Importantly, although AMPARs appeared and diversified in the ancestor of bilateral animals, the ARAS expansion did not occur until much later, in early vertebrate evolution. We propose that the surge in ARASs and consequent increase in AMPAR functionalities, contributed to the increased complexity of vertebrate brains and cognitive functions.
Grants:	Ministerio de Economía y Competitividad BFU2012-34398 Ministerio de Economía y Competitividad BFU2015-69717-P Ministerio de Economía y Competitividad RTI2018-097037-B-100 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1776
Note:	Altres ajuts: Career Integration Grant (ref. 304111), Ramón y Cajal Fellowship (RYC-2011-08391p), IEDI-2017-00822
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	AMPA receptor auxiliary subunit ; TARP ; Cornichon ; Shisa ; Dispanin C ; Phylogeny
Published in:	Open biology, Vol. 10 (october 2020) , ISSN 2046-2441

DOI: 10.1098/rsob.200234
PMID: 33108974

13 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles