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Pàgina inicial > Articles > Articles publicats > AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins |
Data: | 2020 |
Resum: | In mammalian synapses, the function of ionotropic glutamate receptors is critically modulated by auxiliary subunits. Most of these specifically regulate the synaptic localization and electrophysiological properties of AMPA-type glutamate receptors (AMPARs). Here, we comprehensively investigated the animal evolution of the protein families that contain AMPAR auxiliary subunits (ARASs). We observed that, on average, vertebrates have four times more ARASs than other animal species. We also demonstrated that ARASs belong to four unrelated protein families: CACNG-GSG1, cornichon, shisa and Dispanin C. Our study demonstrates that, despite the ancient origin of these four protein families, the majority of ARASs emerged during vertebrate evolution by independent but convergent processes of neo/subfunctionalization that resulted in the multiple ARASs found in present vertebrate genomes. Importantly, although AMPARs appeared and diversified in the ancestor of bilateral animals, the ARAS expansion did not occur until much later, in early vertebrate evolution. We propose that the surge in ARASs and consequent increase in AMPAR functionalities, contributed to the increased complexity of vertebrate brains and cognitive functions. |
Ajuts: | Ministerio de Economía y Competitividad BFU2012-34398 Ministerio de Economía y Competitividad BFU2015-69717-P Ministerio de Economía y Competitividad RTI2018-097037-B-100 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR-14-297 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1776 |
Nota: | Altres ajuts: Career Integration Grant (ref. 304111), Ramón y Cajal Fellowship (RYC-2011-08391p), IEDI-2017-00822 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | AMPA receptor auxiliary subunit ; TARP ; Cornichon ; Shisa ; Dispanin C ; Phylogeny |
Publicat a: | Open biology, Vol. 10 (october 2020) , ISSN 2046-2441 |
13 p, 1.6 MB |