The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex
García-Contreras, Consolación (SGIT-INIA)
Vázquez-Gómez, Marta (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Pesántez-Pacheco, José Luis (Universidad de Cuenca. Faculty of Agricultural Sciences, School of Veterinary Medicine and Zootechnics)
Heras-Molina, Ana (SGIT-INIA)
Encinas, Teresa (Universidad Complutense de Madrid. Facultad de Veterinaria)
Astiz, Susana (SGIT-INIA)
Gonzalez-Bulnes, Antonio (Universidad Complutense de Madrid. Facultad de Veterinaria)

Data:	2020
Resum:	Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses' developmental competence. There is no data on the duration of the effect of this treatment from the prenatal up to the postnatal stages. Therefore, the present trial aimed at determining the impact of metformin treatment on the offspring neonatal traits and early postnatal development (i. e. , during lactation) using an in vivo swine model. The results support that maternal metformin treatment during pregnancy induces protective changes in body shape and composition of the progeny (i. e. , larger head size and body length at birth and higher total viscera weight at weaning). However, there were also major effects of the offspring sex (smaller corpulence in females and lower relative weight of main viscerae in males), which should be considered for further preclinical studies and when even the current clinical application in women affected by PCOS or diabetes is implemented.
Ajuts:	Ministerio de Economía y Competitividad AGL2015-72198-EXP
Nota:	Altres ajuts: GE/FPU014/01285 ; FPI/BES-2014-070464 i FPI/BES-2017-080541
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Models animals per a la investigació ; Porcs ; Ovaris ; Quistos ; Intrauterine growth restriction ; Metformin ; Pregnancy ; Swine model
Publicat a:	Pharmaceuticals, Vol. 13 (november 2020) , ISSN 1424-8247

DOI: 10.3390/ph13110363
PMID: 33158193

11 p, 1.1 MB

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