Cortical responses to noninvasive perturbations enable individual brain fingerprinting
Ozdemir, Recep A. (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Tadayon, Ehsan (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Boucher, Pierre (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Sun, Haoqi (Harvard Medical School)
Momi, Davide (Department of Neuroscience, Imaging and Clinical Sciences, University of Chieti-PescarA)
Ganglberger, Wolfgang (Harvard Medical School)
Westover, M. Brandon (Harvard Medical School)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Santarnecchi, Emiliano (Department of Medicine, Surgery and Neuroscience, University of Siena, Italy)
Shafi, Mouhsin M. (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))

Data:	2021
Resum:	In recent years, it has become increasingly apparent that characterizing individual brain structure, connectivity and dynamics is essential for understanding brain function in health and disease. However, the majority of neuroimaging and brain stimulation research has characterized human brain function by averaging measurements from groups of subjects and providing population-level inferences. External perturbations applied directly to well-defined brain regions can reveal distinctive information about the state, connectivity and dynamics of the human brain at the individual level. In a series of studies, we aimed to characterize individual brain responses to MRI-guided transcranial magnetic stimulation (TMS), and explore the reproducibility of the evoked effects, differences between brain regions, and their individual specificity. In the first study, we administered single pulses of TMS to both anatomically (left dorsolateral prefrontal cortex- 'L-DLPFC', left Intra-parietal lobule- 'L-IPL) and functionally (left motor cortex- 'L-M1', right default mode network- 'R-DMN, right dorsal attention network- 'R-DAN') defined cortical nodes in the frontal, motor, and parietal regions across two identical sessions spaced one month apart in 24 healthy volunteers. In the second study, we extended our analyses to two independent data sets (n = 10 in both data sets) having different sham-TMS protocols. In the first study, we found that perturbation-induced cortical propagation patterns are heterogeneous across individuals but highly reproducible within individuals, specific to the stimulated region, and distinct from spontaneous activity. Most importantly, we demonstrate that by assessing the spatiotemporal characteristics of TMS-induced brain responses originating from different cortical regions, individual subjects can be identified with perfect accuracy. In the second study, we demonstrated that subject specificity of TEPs is generalizable across independent data sets and distinct from non-transcranial neural responses evoked by sham-TMS protocols. Perturbation-induced brain responses reveal unique "brain fingerprints" that reflect causal connectivity dynamics of the stimulated brain regions, and may serve as reliable biomarkers of individual brain function.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Transcranial magnetic stimulation ; Electroencephalography ; TMS evoked Potentials ; Brain fingerprinting
Publicat a:	Brain stimulation, Vol. 14 (february 2021) , p. 391-403, ISSN 1876-4754

DOI: 10.1016/j.brs.2021.02.005
PMID: 33588105

25 p, 4.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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