Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard, Paul (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Rosen, Lindsey B. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Zhang, Qian (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Michailidis, Eleftherios (The Rockefeller University. Laboratory of Virology and Infectious Disease)
Hoffmann, Hans-Heinrich (The Rockefeller University. Laboratory of Virology and Infectious Disease)
Zhang, Yu (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Dorgham, Karim (Sorbonne Université. Centre d'Immunologie et des Maladies Infectieuses)
Philippot, Quentin (University of Paris. Imagine Institute)
Rosain, Jérémie (University of Paris. Imagine Institute)
Béziat, Vivien (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Manry, Jeremy (University of Paris. Imagine Institute)
Shaw, Elana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Haljasmägi, Liis (University of Tartu. Institute of Biomedicine and Translational Medicine)
Peterson, Pärt (University of Tartu. Institute of Biomedicine and Translational Medicine)
Lorenzo, Lazaro (University of Paris. Imagine Institute)
Bizien, Lucy (University of Paris. Imagine Institute)
Trouillet-Assant, Sophie (Lyon University. International Center of Research in Infectiology)
Dobbs, Kerry (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Almeida de Jesus, Adriana (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Belot, Alexandre (Lyon Immunopathology Federation. Hospices Civils de Lyon)
Kallaste, Anne (Internal Medicine Clinic. Tartu University Hospital)
Catherinot, Emilie (Hôpital Foch)
Tandjaoui-Lambiotte, Yacine (Avicenne Hospital. Assistance Publique Hôpitaux de Paris)
Le Pen, Jérémie (The Rockefeller University. Laboratory of Virology and Infectious Disease)
Kerner, Gaspard (University of Paris. Imagine Institute)
Bigio, Benedetta (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Seeleuthner, Yoann (University of Paris. Imagine Institute)
Yang, Rui (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Bolze, Alexandre (Helix)
Spaan, András N. (University Medical Center Utrecht)
Delmonte, Ottavia M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Abers, Michael S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Aiuti, Alessandro (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS))
Casari, Giorgio (Medical Genetics. IRCCS Ospedale San Raffaele)
Lampasona, Vito (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS))
Piemonti, Lorenzo (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS))
Ciceri, Fabio (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS))
Bilguvar, Kaya (Yale University School of Medicine. Department of Genetics)
Lifton, Richard P. (Rockefeller University. Laboratory of Human Genetics and Genomics)
Vasse, Marc (Consorcio Hospital. General Universitario)
Smadja, David M. (Paris University. European Georges Pompidou Hospital)
Migaud, Mélanie (University of Paris. Imagine Institute)
Hadjadj, Jérome (Hôpital Cochin. Department of Internal Medicine)
Terrier, Benjamin (Université de Paris. Department of Internal Medicine)
Duffy, Darragh (Pasteur Institute)
Quintana-Murci, Lluis (Institut Pasteur. Collège de France)
van de Beek, Diederik (Amsterdam UMC. University Medical Center)
Roussel, Lucie (McGill University Health Centre)
Vinh, Donald C. (McGill University Health Centre)
Tangye, Stuart (Garvan Institute of Medical Research (Darlinghurst, Austràlia))
Haerynck, Filomeen (Ghent University Hospital. (Bèlgica))
Dalmau, David (Fundació Docència i Recerca Mútua Terrassa)
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Brodin, Petter (Karolinska Institutet (Estocolm, Suècia))
Nussenzweig, Michel (Howard Hughes Medical Institute)
Boisson-Dupuis, Stephanie (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases)
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín)
Vogt, Guillaume (University of Paris. Neglected Human Genetics Laboratory)
Mogensen, Trine Hyrup (Aarhus University)
Oler, Andrew J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH)
Gu, Jingwen (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH)
Burbelo, Peter D. (Division of Intramural Research. National Institute of Dental Craniofacial Research (NIDCR). NIH)
Cohen, Jeffrey I. (Laboratory of Infectious Diseases. Division of Intramural Research. NIAID. NIH)
Biondi, Andrea (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale)
Bettini, Laura Rachele (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale)
D'Angio, Mariella (University of Milano-Bicocca. Pediatric Department)
Bonfanti, Paolo (University of Milano-Bicocca. Department of Infectious Diseases)
Rossignol, Patrick (University of Lorraine. Plurithematic Clinical Investigation Centre)
Mayaux, Julien (APHP Pitié-Salpêtrière Hospital)
Rieux-Laucat, Frédéric (Laboratory of Immunogenetics of Pediatric Autoimmune Diseases. INSERM. UMR 1163. University of Paris. Imagine Institute)
Husebye, Eystein (Karolinska Institutet (Estocolm, Suècia). Department of Medicine)
Fusco, Francesca (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR)
Ursini, Matilde Valeria (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR)
Imberti, Luisa (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia)
Sottini, Alessandra (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia)
Paghera, Simone (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia)
Quiros-Roldan, Eugenia (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia)
Rossi, Camillo (Direzione Sanitaria. ASST Spedali Civili di Brescia)
Castagnoli, Riccardo (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia)
Montagna, Daniela (Department of Clinical. Surgical. Diagnostic and Pediatric Sciences. University of Pavia)
Licari, Amelia (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia)
Marseglia, Gian Luigi (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia)
Duval, Xavier (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP)
Ghosn, Jade (Hôpital Bichat)
Tsang, John S. (Multiscale Systems Biology Section. Laboratory of Immune System Biology. NIAID. NIH)
Goldbach-Mansky, Raphaela (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Kisand, Kai (Institute of Biomedicine and Translational Medicine. University of Tartu)
Lionakis, Michail S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Puel, Anne (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Zhang, Shein-Ying (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Holland, Steven M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Gorochov, Guy (Département d'Immunologie. AP-HP. Hôpital Pitié-Salpétrière)
Jouanguy, Emmanuelle (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Rice, Charles M. (Laboratory of Virology and Infectious Disease. The Rockefeller University)
Cobat, Aurélie (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Abel, Laurent (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica))
Casanova, Jean-Laurent (Pediatric Hematology and Immunology Unit. Necker Hospital for Sick Children. AP-HP)
The University of Hong Kong HGID Lab
The University of Hong Kong NIAID-USUHS Immune Response to COVID Group
COVID Clinicians
COVID-STORM Clinicians
Imagine COVID Group
French COVID Cohort Study Group
The Milieu Intérieur Consortium
CoV-Contact Cohort
Amsterdam UMC Covid-19 Biobank
COVID Human Genetic Effort
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2. 6% of women and 12. 5% of men.
Ajuts:	Instituto de Salud Carlos III COV20_01333 Instituto de Salud Carlos III COV20_01334 Ministerio de Ciencia e Innovación RTC-2017-6471-1
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing ; Asymptomatic Infections ; Autoantibodies ; Betacoronavirus ; Case-Control Studies ; Coronavirus Infections ; COVID-19 ; Critical Illness ; Female ; Humans ; Immunoglobulin G ; Interferon alpha-2 ; Interferon Type I ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral
Publicat a:	Science, Vol. 370 Núm. 6515 (september 2020) , p. eabd4585, ISSN 1095-9203

DOI: 10.1126/science.abd4585
PMID: 32972996

17 p, 2.5 MB

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