Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang, Qian (St. Rockefeller University)
Bastard, Paul (University of Paris)
Liu, Zhiyong (Rockefeller University (Estats Units d'Amèrica))
Le Pen, Jérémie (Rockefeller University (Estats Units d'Amèrica))
Moncada-Velez, Marcela (Rockefeller University (Estats Units d'Amèrica))
Chen, Jie (Rockefeller University (Estats Units d'Amèrica))
Ogishi, Masato (Rockefeller University (Estats Units d'Amèrica))
Sabli, Ira K. D. (Imperial College London)
Hodeib, Stephanie (Imperial College London)
Korol, Cecilia (Necker Hospital for Sick Children (París))
Rosain, Jérémie (University of Paris)
Bilguvar, Kaya (Yale School of Medicine)
Ye, Junqiang (Columbia University (Estats Units d'Amèrica))
Bolze, Alexandre (Helix)
Bigio, Benedetta (Rockefeller University (Estats Units d'Amèrica))
Yang, Rui (Rockefeller University (Estats Units d'Amèrica))
Arias, Andrés Augusto (Universidad de Antioquia)
Zhou, Qinhua (Rockefeller University)
Zhang, Yu (NIAID Clinical Genomics Program)
Onodi, Fanny (Université de Paris)
Korniotis, Sarantis (Université de Paris)
Karpf, Léa (Université de Paris)
Philippot, Quentin (University of Paris)
Chbihi, Marwa (University of Paris)
Bonnet-Madin, Lucie (Université de Paris)
Dorgham, Karim (Sorbonne Université (París))
Smith, Nikaïa (Institut Pasteur)
Schneider, William M. (Rockefeller University (Estats Units d'Amèrica))
Razooky, Brandon S. (Rockefeller University (Estats Units d'Amèrica))
Hoffmann, Hans-Heinrich (Rockefeller University (Estats Units d'Amèrica))
Michailidis, Eleftherios (Rockefeller University (Estats Units d'Amèrica))
Moens, Leen (University Hospitals Leuven (Bèlgica))
Han, Ji Eun (Rockefeller University (Estats Units d'Amèrica))
Lorenzo, Lazaro (University of Paris)
Bizien, Lucy (University of Paris)
Meade, Philip (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Neehus, Anna-Lena (University of Paris)
Ugurbil, Aileen Camille (Rockefeller University (Estats Units d'Amèrica))
Corneau, Aurélien (Sorbonne Université (París))
Kerner, Gaspard (University of Paris)
Zhang, Peng (Rockefeller University (Estats Units d'Amèrica))
Rapaport, Franck (Rockefeller University (Estats Units d'Amèrica))
Seeleuthner, Yoann (University of Paris)
Manry, Jeremy (University of Paris)
Masson, cecile (Imagine Institute)
Schmitt, Yohann (Université de Paris)
Schlüter, Agatha (Institut d'Investigació Biomèdica de Bellvitge)
Le Voyer, Tom (University of Paris)
Khan, Taushif (Sidra Medicine (Doha, Qatar))
Li, Juan (Rockefeller University (Estats Units d'Amèrica))
Fellay, Jacques (Lausanne University Hospital (Suïssa))
Roussel, Lucie (McGill University Health Centre (Quebec, Canadà))
Shahrooei, Mohammad (Sina Medical Complex (Iran))
Alosaimi, Mohammed F. (King Saud University (Aràbia Saudita))
Mansouri, Davood (Shahid Beheshti University of Medical Sciences (Teheran, Iran))
Al-Saud, Haya (National Center of Genomics Technology (Riad, Aràbia Saudita))
Al-Mulla, Fahd (Dasman Diabetes Institute ( Kuwait))
Almourfi, Feras (National Center of Genomics Technology (Riad, Aràbia Saudita))
Al-Muhsen, Saleh Zaid (King Saud University Medical City (Aràbia Saudita))
Alsohime, Fahad (King Saud University (Aràbia Saudita))
Al Turki, Saeed (King Abdullah International Medical Research Center(Aràbia Saudita))
Hasanato, Rana (King Saud University (Aràbia Saudita))
van de Beek, Diederik (University Medical Center (Amsterdam, Païssos Baixos))
Biondi, Andrea (MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (Monza, Itàlia))
Bettini, Laura Rachele (MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (Monza, Itàlia))
D'Angio, Mariella (MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (Monza, Itàlia))
Bonfanti, Paolo (University of Milano-Bicocca (Monza, Itàlia))
Imberti, Luisa (Azienda Ospedaliera Spedali Civili di Brescia (Brescia, Itàlia))
Sottini, Alessandra (Azienda Ospedaliera Spedali Civili di Brescia (Brescia, Itàlia))
Paghera, Simone (Azienda Ospedaliera Spedali Civili di Brescia (Brescia, Itàlia))
Quiros-Roldan, Eugenia (University of Brescia (Itàlia))
Rossi, Camillo (Azienda Ospedaliera Spedali Civili di Brescia (Brescia, Itàlia))
Oler, Andrew J. (Office of Cyber Infrastructure and Computational Biology (Bethesda, Estats Units d'Amèrica))
Tompkins, Miranda F. (Uniformed Services University of the Health Sciences (Bethesda, Estats Units d'Amèrica))
Alba, Camille (Uniformed Services University of the Health Sciences (Bethesda, Estats Units d'Amèrica))
Vandernoot, Isabelle (Université Libre de Bruxelles (Bèlgica))
Goffard, Jean-Christope (Université Libre de Bruxelles (Bèlgica))
Smits, Guillaume (Université Libre de Bruxelles (Bèlgica))
Migeotte, Isabelle (Université Libre de Bruxelles (Bèlgica))
Haerynck, Filomeen (Ghent University Hospital (Gant, Bèlgica))
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron)
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron)
Morange, Pierre-Emmanuel (Aix Marseille Univ (Marsella, França))
Keles, Sevgi (Necmettin Erbakan University (Turquia))
Ozcelik, Tayfun (Bilkent University (Turquia))
Kadriye, Kart Yaşar (University of Health Sciences (Estambul))
Senoglu, Sevtap (University of Health Sciences (Estambul))
Karabela, Şemsi Nur (University of Health Sciences (Estambul))
Rodríguez-Gallego, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín)
Novelli, Giuseppe (University of Rome "Tor Vergata (Itàlia))
Hraiech, Sami (Intensive Care Unit (Marsella, França))
Tandjaoui-Lambiotte redondo, Yacine (Avicenne Hospital Intensive Care Unit (París))
Duval, Xavier (Université de Paris)
Laouénan, Cédric (Hôpital Bichat (París))
Foti, Giuseppe (University of Milano-Bicocca (Monza, Itàlia))
Bellani, Giacomo (University of Milano-Bicocca (Monza, Itàlia))
Citerio, Giuseppe (University of Milano-Bicocca (Monza, Itàlia))
Contro, Ernesto (University of Milano-Bicocca (Monza, Itàlia))
Pesci, Alberto (University of Milano-Bicocca (Monza, Itàlia))
Valsecchi, Maria Grazia (University of Milano-Bicocca (Monza, Itàlia))
Cazzaniga, Marina (University of Milano-Bicocca (Monza, Itàlia))
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra)
Akcan, Ozge Metin (Necmettin Erbakan University (Turquia))
Darazam, Ilad Alavi (Shahid Beheshti University of Medical Sciences (Teheran, Iran))
Aldave, Juan C. (Hospital Nacional Edgardo Rebagliati Martins)
Ramos, Miquel Alfonso (Parc Sanitari Sant Joan de Déu)
Nadji, Seyed Alireza (Shahid Beheshti University of Medical Sciences (Teheran, Iran))
Alkan, Gulsum (Selcuk University)
Allardet-Servent, Jerome (Hôpital Européen)
Allende-Martinez, Luis M. (Hospital Universitario 12 de Octubre (Madrid))
Alsina Manrique, Laia (Hospital Sant Joan de Déu (Manresa))
Alyanakian, Marie-Alexandra (Necker Hospital for Sick Children (París))
Amador Borrero, Blanca (Université de Paris)
Amoura, Zahir (Internal Medicine Department. Pitié-Salpétrière Hospital)
Antolí, Arnau (Hospital Universitari de Bellvitge)
Arslan, Sevket (Necmettin Erbakan University)
Assant, Sophie (Lyon Sud Hospital)
Auguet, Teresa (Hospital Universitari Joan XXIII de Tarragona)
Azot, Axelle (Private Practice)
Bajolle, Fanny (Necker Hospital for Sick Children (París))
Baldolli, Aurélie (CHU de Caen (França))
Ballester, Maite (Consorcio Hospital General Universitario (València))
Feldman, Hagit Baris (Tel Aviv University ( Israel))
Barrou, Benoit (Sorbonne Université (París))
Beurton, Alexandra (Hôpital Pitié-Salpêtrière (París))
Bilbao, Agurtzane (Hospital Universitario de Cruces (Barakaldo, País Basc))
Blanchard-Rohner, Geraldine (Geneva University Hospitals (Suïssa))
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Blandinières, Adeline (Georges Pompidou Hospital (París))
Blázquez-Gamero, Daniel (Hospital Universitario 12 de Octubre (Madrid))
Bloomfield, Marketa (Motol University Hospital (República Txeca))
Bolivar-Prados, Mireia (Hospital de Mataró. Consorci Sanitari del Maresme)
Borie, Raphael (Hopital Bichat (París))
Bosteels, Cédric (Ghent University Hospital (Gant, Bèlgica))
Bousfiha, Ahmed A. (Hassann II University (Casablanca, Marroc))
Bouvattier, Claire (APHP Hôpitaux Universitaires Paris-Sud (França))
Boyarchuk, Oksana (I. Horbachevsky Ternopil National Medical University (Ucrània))
Bueno, Maria Rita P. (Universidade de São Paulo)
Cáceres Agra, Juan José (Hospital Universitario Insular de Gran Canaria)
Calimli, Semra (Konya State Hospital (Turquia))
Capra, Ruggero (Azienda Ospedaliera Spedali Civili di Brescia (Brescia, Itàlia))
Carrabba, Maria (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Casasnovas, Carlos (Hospital Universitari de Bellvitge)
Caseris, Marion (Hopital Robert Debré (París))
Castelle, Martin (Necker Enfants Malades Hospital (París))
Castelli, Francesco (University of Brescia (Itàlia))
Castillo de Vera, Martín (Servicio Canario de la Salud (Les Palmes de Gran Canària))
Castro, Mateus V. (Universidade de São Paulo)
Catherinot, Emilie (Hôpital Foch (França))
Chalumeau, Martin (Necker Hospital for Sick Children (París))
Charbit, Bruno (Pasteur Institute (París))
Cheng, Matthew P. (McGill University Health Centre (Canadà))
Clavé i Civit, Pere (Hospital de Mataró. Consorci Sanitari del Maresme)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Codina, Anna (Institut de Recerca Sant Joan de Déu)
Colkesen, Fatih (Necmettin Erbakan University (Turquia))
Çölkesen, Fatma (Konya Training and Research Hospital (Turquia))
Comarmond, Cloé (Pitié-Salpêtrière Hospital (París))
Dalmau, David (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Darley, David Ross (St Vincent's Hospital Sydney (Austràlia))
Dauby, Nicolas (Université Libre de Bruxelles (Bèlgica))
Dauger, Stéphane (Robert-Debré University Hospital (París))
de Pontual, Loic (Hôpital Jean Verdier (França))
Dehban, Amin (Sina Medical Complex (Iran))
Delplancq, Geoffroy (Centre de Génétique Humaine (França))
Demoule, Alexandre (Sorbonne Université Médecine (França))
Diehl, Jean-Luc (Georges Pompidou Hospital (París))
Dobbelaere, Stephanie (AZ Delta (Bèlgica))
Durand, Sophie (Institut Jérôme Lejeune (París))
Eldars, Waleed (Mansoura University (Egipte))
Elgamal, Mohamed (Mansoura University (Egipte))
Elnagdy, Marwa H. (Mansoura University (Egipte))
Emiroglu, Melike (Selcuk University (Turquia))
Erdeniz, Emine Hafize (Ondokuz Mayıs University (Turquia))
Erol Aytekin, Selma (Necmettin Erbakan University (Turquia))
Euvrard, Romain (Centre Hospitalier Fleyriat (França))
Evcen, Recep (Necmettin Erbakan University (Turquia))
Fabio, Giovanna (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Faivre, Laurence (CHU Dijon (França))
Falck, Antonin (Hopital Robert Debré (París))
Fartoukh, Muriel (APHP Tenon Hospital (París))
Faure, Morgane (Sorbonne Universités (París))
Fernández Arquero, Miguel (Hospital Clínico San Carlos (Madrid))
Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Francois, Bruno (CHU Limoges (França))
Fumadó, Victoria (Universitat de Barcelona)
Fusco, Francesca (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso (Nàpoles,Itàlia))
García Solis, Blanca (Hospital Universitario La Paz (Madrid))
Gaussem, Pascale (Hôpital Européen Georges Pompidou (París, França))
Gil-Herrera, Juana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Gilardin, Laurent (Bégin Military Hospital (França))
Girona-Alarcón, Mònica (Hospital Sant Joan de Déu (Manresa))
Gok, Funda (Necmettin Erbakan University (Turquia))
González Montelongo, Rafaela (Instituto Tecnológico y de Energías Renovables (Santa Cruz de Tenerife))
Guerder, Antoine (Assistance-Publique Hôpitaux de Paris)
Gul, Yahya (Necmettin Erbakan University (Turquia))
Guner, Sukru Nail (Necmettin Erbakan University (Turquia))
Gut, Marta (Centre de Regulació Genòmica)
Hadjadj, Jérôme (Hôpital Cochin (París))
Halwani, Rabih (University of Sharjah (Emirats Àrabs Units))
Hammarström, Lennart (Karolinska Institutet (Estocolm, Suècia))
Nevin, Hatipoglu (University of Health Sciences (Turquia))
Hernandez-Brito, Elisa (Hospital Universitario de Gran Canaria Dr. Negrín)
Heijmans, Cathérine (Jolimont Hospital (Bèlgica))
Holanda-Peña, María Soledad (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Horcajada, Juan Pablo (Hospital del Mar (Barcelona, Catalunya))
Hoste, Levi (Ghent University Hospital (Gant, Bèlgica))
Hoste, Eric (Ghent University Hospital (Gant, Bèlgica))
Hraiech, Sami (Assistance publique-Hôpitaux de Marseille (França))
Humbert, Linda (CHU Lille)
Iglesias, Alejandro D. (Columbia University (Estats Units d'Amèrica))
Íñigo-Campos, Antonio (Instituto Tecnológico y de Energías Renovables (Santa Cruz de Tenerife))
Jamme, Matthieu (Centre Hospitalier Intercommunal Poissy Saint Germain en Laye (França))
Arranz, María Jesús (Fundació Docència i Recerca Mútua Terrassa (Terrassa, Catalunya))
Jordán García, Iolanda (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Jorens, Philippe (University Hospital Antwerp (Bèlgica))
Kanat, Fikret (Selcuk University (Turquia))
Kapakli, Hasan (Balikesir Ataturk City Hospital (Turquia))
Kara, Iskender (Selcuk University (Turquia))
Karbuz, Adem (Prof. Dr. Cemil Tascıoglu City Hospital (Turquia))
Kendir Demirkol, Yasemin (Health Sciences University (Turquia))
Klocperk, Adam (Charles University and University Hospital in Motol (República Txeca))
Król, Zbigniew J. (Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw (Polònia))
Kuentz, Paul (CHU Besançon (França))
Kwan, Mike Yat Wah (Hospital Authority Infectious Disease Center.Princess Margaret Hospital (Hong Kong, Xina))
Lagier, Jean-Christophe (Aix Marseille University (França))
Lambrecht, Bart N. (Ghent University Hospital (Gant, Bèlgica))
Lau, Yu Lung (University of Hong Kong)
Le Bourgeois, Fleur (Robert-Debré University Hospital (París))
Leo, Yee-Sin (National Centre for Infectious Diseases (Singapur))
Leon Lopez, Rafael (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Leung, Daniel (University of Hong Kong)
Levin, Michael (Imperial College (Londres, Regne Unit))
Levy, Michael (Robert-Debré University Hospital (París))
Lévy, Romain (Necker Hospital for Sick Children)
Li, Zhi (Pasteur Institute (París))
Linglart, Agnès (Bicêtre Paris-Saclay Hospital (França))
Loeys, Bart (University Hospital Antwerp (Bèlgica))
Lorenzo-Salazar, José Miguel (Instituto Tecnológico y de Energías Renovables (Santa Cruz de Tenerife))
Louapre, Céline (Paris University)
Lubetzki, Catherine (Paris University)
Luyt, Charles-Edouard (Sorbonne Université)
Lye, David C. (Tan Tock Seng Hospital (Singapur))
Marjani, Majid (Shahid Beheshti University of Medical Sciences (Teheran, Iran))
Marquez Pereira, Jesús (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Martínez Pueyo, David (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Marzana, Iciar (Hospital Universitario de Cruces (Barakaldo, País Basc))
Mathian, Alexis (Pitié-Salpétrière Hospital (París, França))
Matos, Larissa R. B. (Universidade de São Paulo)
Matthews, Gail V. (University of New South Wales (Austràlia))
Mayaux, Julien (APHP Pitié-Salpêtrière Hospital (París))
Mège, Jean-Louis (Aix-Marseille University (França))
Melki, Isabelle (Robert-Debré University Hospital (París))
Meritet, Jean-François (APHP Cohin Hospital (París))
Meyts, Isabelle (University Hospitals Leuven (Bèlgica))
Mezidi, Mehdi (Hôpital de la Croix-Rousse (França))
Millereux, Maude (CH Gonesse (França))
Mirault, Tristan (Georges Pompidou Hospital (París))
Mircher, Clotilde (Institut Jérôme Lejeune (París))
Mirsaeidi, Mehdi (University of Miami)
Montesdeoca Melián, Abián (Servicio Canario de la Salud (Les Palmes de Gran Canària))
Morales Martínez, Antonio (Hospital Universitario Regional de Málaga (Andalusia))
Mordacq, Clémence (CHU Lille)
Morelle, Guillaume (University of Paris Saclay (França))
Mouly, Stéphane (Université de Paris)
Muñoz-Barrera, Adrián (Instituto Tecnológico y de Energías Renovables (Santa Cruz de Tenerife))
Naesens, Leslie (Ghent University Hospital (Gant, Bèlgica))
Nafati, Cyril (CHU de La Timone (França))
Farela Neves, João (Centro Hospitalar Universitário de Lisboa Central (Portugal))
FP. Ng, Lisa (Infectious Diseases Horizontal Technlogy Centre. A*STAR (Singapur))
Novoa Medina, Yeray (Complejo Hospitalario Universitario Insular Materno Infantil (Las Palmas de Gran Canaria))
Nuñez Cuadros, Esmeralda (Servicio Canario de la Salud (Les Palmes de Gran Canària))
Ocejo-Vinyals, J. Gonzalo (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Orbak, Zerrin (Ataturk University (Turquia))
Oualha, Mehdi (Necker Hospital for Sick Children (París))
Pan-Hammarström, Qiang (Karolinska Institutet (Estocolm, Suècia))
Parizot, Christophe (APHP Pitié-Salpêtrière Hospital (París))
Pascreau, Tiffany (L'Hôpital Foch (França))
Paz-Artal, Estela (Hospital Universitario 12 de Octubre (Madrid))
Pellegrini, Sandra (Pasteur Institute (París))
Perez de Diego, Rebeca (Instituto de Investigación Sanitaria del Hospital Universitario La Paz (Madrid))
Philippe, Aurélien (APHP Hôpitaux Universitaires Paris-Sud (França))
Planas-Serra, Laura (Institut d'Investigació Biomèdica de Bellvitge)
Ploin, Dominique (Hospices Civils de Lyon (França))
Poissy, Julien (Université de Lille (França))
Poncelet, Géraldine (Hopital Robert Debré (París))
Pouletty, Marie (University Hospital Robert Debré (París))
Quentric, Paul (APHP Pitié-Salpêtrière Hospital (París))
Raoult, Didier (Aix-Marseille University (França))
Rebillat, Anne-Sophie (Institut Jérôme Lejeune (París))
Reisli, Ismail (Necmettin Erbakan University (Turquia))
Ricart, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Richard, Jean-Christophe (Hospices Civils de Lyon (França))
Rivet, Nadia (Georges Pompidou Hospital (París))
Rivière, Jacques G. (Hospital Universitari Vall d'Hebron)
Rocamora Blanch, Gemma (Hospital Universitari de Bellvitge)
Rodrigo Gonzalo de Líria, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez-Palmero, Agustí (Institut d'Investigació Biomèdica de Bellvitge)
Romero, Carolina Soledad (Hospital General Universitario de Valencia)
Rothenbuhler, Anya (Hôpitaux Universitaires Paris-Sud (París))
Rozenberg, Flore (Université de Paris(França))
Ruiz del Prado, María Yolanda (Hospital San Pedro (Logroño, La Rioja))
Sabater-Riera, Joan (Institut d'Investigació Biomèdica de Bellvitge)
Sánchez, Oliver (Georges Pompidou Hospital (París, França))
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid))
Schmidt, Matthieu (Hopital Pitié-Salpêtrière (París, França))
Schweitzer, Cyril E. (CHRU de Nancy (França))
Scolari, Francesco (University of Brescia (Itàlia))
Sediva, Anna (Charles University (República Txeca))
Seijo, Luis M. (Clínica Universidad de Navarra (Madrid))
Sene, Damien (Université de Paris)
Seppänen, Mikko R. J. (HUS Helsinki University Hospital (Finlàndia))
Serra Ilovich, Alex (Fundació Docència i Recerca Mútua Terrassa)
Shahrooei, Mohammed (Sina Medical Complex (Iran))
Slabbynck, Hans (ZNA Middelheim, Antwerp (Bèlgica))
Smadja, David M. (Hôpital Européen Georges Pompidou (París, França))
Sobh, Ali (Mansoura University (Egipte))
Solanich, Xavier (Hospital Universitari de Bellvitge)
Dalgard, Clifton L. (Uniformed Services University of the Health Sciences ((Bethesda, Estats Units d'Amèrica))
Milner, Joshua D. (Columbia University Estats Units d'Amèrica))
Vinh, Donald C. (McGill University Health Centre (Quebec, Canadà))
Mogensen, Trine Hyrup (Aarhus University Hospital (Aarhus, Dinamarca))
Marr, Nico (Hamad Bin Khalifa University (Qatar))
Spaan, András (The Rockefeller University (Estats Units d'Amèrica))
Boisson, Bertrand (University of Paris)
Boisson-Dupuis, Stephanie (University of Paris)
Bustamante, Jacinta (The Rockefeller University (Estats Units d'Amèrica))
Puel, Anne (The Rockefeller University (Estats Units d'Amèrica))
Ciancanelli, Michael J. (The Rockefeller University (Estats Units d'Amèrica))
Maniatis, Tom (Columbia University (Estats Units d'Amèrica))
Soumelis, Vassili (Université de Paris)
Amara, Ali (Université de Paris)
Nussenzweig, Michel (The Rockefeller University (Estats Units d'Amèrica))
Garcia-Sastre, Adolfo (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Krammer, Florian (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge)
Duffy, Darragh (Institut Pasteur (París))
Lifton, Richard P. (The Rockefeller University (Estats Units d'Amèrica))
Zhang, Shen-Ying (The Rockefeller University (Estats Units d'Amèrica))
Gorochov, Guy (Sorbonne Université (París, França))
Béziat, Vivien (The Rockefeller University (Estats Units d'Amèrica))
Jouanguy, Emmanuelle (The Rockefeller University (Estats Units d'Amèrica))
Sancho Shimizu, Vanessa (Imperial College London)
Rice, Charles M. (The Rockefeller University (Estats Units d'Amèrica))
Abel, Laurent (The Rockefeller University (Estats Units d'Amèrica))
Notarangelo, Luigi (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica))
Cobat, Aurélie (The Rockefeller University (Estats Units d'Amèrica))
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica))
Casanova, Jean-Laurent (The Rockefeller University (Estats Units d'Amèrica))
Zhang, S. Y. (University of Paris)
Blanch, G. R. (Hospital Universitari de Bellvitge)
Riera, J. S. (Hospital Universitari de Bellvitge)
Ballester Devis, Maria (Consorcio Hospital General Universitario)
van Braeckel, E. (Universitair Ziekenhuis Gent)
Vincent, Amy (APHP Hôpitaux Universitaires Paris-Sud)
Zatz, Mayana (Universidade de São Paulo)
Vélez-Santamaria, V. (Hospital Universitari de Bellvitge)
Toubiana, J. (Necker Hospital for Sick Children (París))
Vilaire, M. E. (Institut Jérôme Lejeune)
Ursini, Matilde Valeria (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso)
de Diego, R. P. (Hospital Universitario La Paz (Madrid))
van Den Rym, A. M. (Hospital Universitario La Paz (Madrid))
Yosunkaya, A. (Necmettin Erbakan University (Turquia))
Thy, M. (Center for Clinical Investigation. Assistance Publique - Hôpitaux de Paris)
van Agtmael, Michiel (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Bomers, Marije (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Chouchane, Osoul (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Geerlings, Suzanne (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Goorhuis, Bram (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Grobusch, Martin P. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Harris, Vanessa (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Hermans, Sabine M. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Hovius, Joppe W. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Nellen, Jeaninne (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Peters, Edgar (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
van der Poll, Tom (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Prins, Jan M. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Reijnders, Tom (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Schinkel, Michiel (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Sigaloff, Kim (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Stijnis, Cornelis S. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
van der Valk, Marc (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
van Vugt, Michèle (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Joost Wiersinga, W. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Algera, Anna Geke (Amsterdam University Medical Center (UMC))
van Baarle, Frank (Amsterdam University Medical Center (UMC))
Bos, Lieuwe D. (Amsterdam University Medical Center (UMC))
Botta, Michela (Amsterdam University Medical Center (UMC))
de Bruin, Sanne (Amsterdam University Medical Center (UMC))
Bulle, Esther (Amsterdam University Medical Center (UMC))
Elbers, Paul (Amsterdam University Medical Center (UMC))
Fleuren, Lucas (Amsterdam University Medical Center (UMC))
Girbes, Armand (Amsterdam University Medical Center (UMC))
Hagens, Laura (Amsterdam University Medical Center (UMC))
Heunks, Leo (Amsterdam University Medical Center (UMC))
Horn, Janneke (Amsterdam University Medical Center (UMC))
van Mourik, Niels (Amsterdam University Medical Center (UMC))
Paulus, Frederique (Amsterdam University Medical Center (UMC))
Raasveld, Jorinde (Amsterdam University Medical Center (UMC))
Schultz, Marcus J. (Amsterdam University Medical Center (UMC))
Smit, Marry (Amsterdam University Medical Center (UMC))
Stilma, Willemke (Amsterdam University Medical Center (UMC))
Thoral, Patrick (Amsterdam University Medical Center (UMC))
Tsonas, Anissa M. (Amsterdam University Medical Center (UMC))
de Vries, Heder (Amsterdam University Medical Center (UMC))
Bax, Diane (Experimental Immunology. Amsterdam UMC)
Cloherty, Alex (Experimental Immunology. Amsterdam UMC)
Beudel, Martijn (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos). Amsterdam Neuroscience)
Brouwer, Matthijs C. (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos). Amsterdam Neuroscience)
Koning, Rutger (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos). Amsterdam Neuroscience)
Bogaard, H. J. (Amsterdam UMC. University Medical Center. Department of Pulmonology)
de Brabander, J. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
de Bree, G. (Amsterdam University Medical Center (UMC). Department of Infectious Diseases)
Bugiani, Marianna (Amsterdam University Medical Centre)
Geerts, Bart (Amsterdam University Medical Center. Department of Anesthesiology)
Hollmann, Markus W. (Amsterdam University Medical Center. Department of Anesthesiology)
Preckel, Benedikt (Amsterdam University Medical Center. Department of Anesthesiology)
Veelo, Denise (Amsterdam University Medical Center. Department of Anesthesiology)
Geijtenbeek, Theo (Amsterdam University Medical Center (UMC). Department of Experimental Immunology)
Hafkamp, Florianne (Amsterdam University Medical Center (UMC). Department of Experimental Immunology)
Hamann, Jorg (Amsterdam University Medical Center (UMC) Biobank Core Facility)
Hemke, Robert (Amsterdam University Medical Center (UMC))
de Jong, Menno D. (Amsterdam University Medical Center (UMC))
Schuurman, Alex (Amsterdam University Medical Center (UMC))
Teunissen, Charlotte E. (Neurochemical Laboratory. Amsterdam UMC)
Vlaar, Alexander P. J. (Amsterdam University Medical Center (UMC))
Wouters, Dorien (Amsterdam University Medical Center (UMC). Department of Clinical Chemistry)
Zwinderman, Aeilko Having Koos (Amsterdam University Medical Center (UMC). Department of Clinical Epidemiology. Biostatistics and Bioinformatics)
Aiuti, Alessandro (San Raffaele Telethon Institute for Gene Therapy. IRCCS Ospedale San Raffaele)
Muhsen, Saleh Al (King Saud University)
Anderson, Mark S. (University of California. San Francisco)
Bogunovic, Dusan (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Itan, Yuval (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Cirulli, Elizabeth (Helix)
Barrett, Kelly Schiabor (Helix)
Washington, Nicole (Helix)
Bondarenko, Anastasiia (Shupyk National Medical Academy for Postgraduate Education)
Bousfiha, Ahmed A. (Clinical Immunology Unit. Pediatric Infectious Disease Departement. Faculty of Medicine and Pharmacy. Averroes University Hospital. LICIA Laboratoire d'Immunologie Clinique. D'Inflammation et d'Allergie. Hassann II University)
Brodin, Petter (Karolinska Institutet (Estocolm, Suècia))
Bryceson, Yenan (Karolinska Institutet (Estocolm, Suècia))
Bustamante, Carlos D. (Stanford University)
Butte, Manish J. (University of California)
Casari, Giorgio (IRCCS Ospedale San Raffaele)
Chakravorty, Samya (Emory University. Department of Pediatrics. Children's Healthcare of Atlanta)
Christodoulou, John (Murdoch Children's Research Institute)
Le Mestre, S. (Universidade de São Paulo)
Condino-Neto, Antonio (Universidade de São Paulo)
Cooper, Megan A. (Washington University School of Medicine)
David, Alessia (Centre for Bioinformatics and System Biology. Department of Life Sciences. Imperial College London. South Kensington Campus)
DeRisi, Joseph L. (Chan Zuckerberg Biohub)
Desai, Murkesh (Bai Jerbai Wadia Hospital for Children)
Drolet, Beth A. (School of Medicine and Public Health. University of Wisconsin)
Espinosa, Sara (Instituto Nacional de Pediatria. (National Institute of Pediatrics))
Franco, Jose Luis (University of Antioquia)
Gregersen, Peter K. (Feinstein Institute for Medical Research. Northwell Health USA)
Hagin, David (Genetics Institute. Tel Aviv Sourasky Medical Center)
Heath, Jim (Institute for Systems Biology)
Henrickson, Sarah E. (Children's Hospital of Philadelphia (Pennsilvània))
Hsieh, Elena (Anschutz Medical Campus)
Imai, Kohsuke (Riken)
Karamitros, Timokratis (Hellenic Pasteur Institute)
Kisand, Kai (University of Tartu)
Ku, Cheng-Lung (Chang Gung University)
Ling, Yun (Shanghai Public Health Clinical Center. Fudan University)
Lucas, Carrie L. (Yale School of Medicine)
Marodi, Laszlo (Semmelweis University Budapest)
Mironska, Kristina (University Clinic for Children's Diseases)
Morio, Tomohiro (Tokyo Medical & Dental University Hospital)
Novelli, Antonio (Bambino Gesù Children's Hospital)
O'Farrelly, Cliona (Trinity College Dublin)
Okada, Satoshi (Hiroshima University)
Planas, Anna Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Prando, Carolina (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe)
Quintana-Murci, Lluis (Institut Pasteur. Collège de France)
Renia, Laurent (Infectious Diseases Horizontal Technology Center. Singapore Immunology Network. Agency for Science Technology (A*STAR))
Renieri, Alessandra (Medical Genetics. University of Siena)
Sankaran, Vijay (Boston Children's Hospital (Boston, Estats Units d'Amèrica))
Snow, Andrew (Uniformed Services University of the Health Sciences)
Tangye, Stuart (Garvan Institute of Medical Research (Darlinghurst, Austràlia))
Turvey, Stuart (University of British Columbia)
Uddin, Furkan (Holy Family Red Crescent Medical College. Centre for Precision Therapeutics. NeuroGen Children's Healthcare. Genetics and Genomic Medicine Centre. NeuroGen Children's Healthcare)
Uddin, Mohammed J. (Centre for Applied Genomics. Department of Genetics and Genome Biology. Hospital for Sick Children)
Vazquez, Sara E. (University of California)
von Bernuth, Horst (Charité-Universitätsmedizin Berlin)
Zawadzki, Pawel (Molecular Biophysics Division. Faculty of Physics. A. Mickiewicz University)
Jing, Huie (NIAID Clinical Genomics Program. National Institutes of Health)
Tung, W. (NIAID Clinical Genomics Program. National Institutes of Health)
Meguro, K. (NIAID Clinical Genomics Program. National Institutes of Health)
Shaw, E. (NIAID Clinical Genomics Program. National Institutes of Health)
Jing, Huie (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Tung, Wesley (NIAID Clinical Genomics Program. National Institutes of Health)
Shafer, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Zheng, L. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Zhang, Z. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Kubo, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Chauvin, S. D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Shaw, Elana (NIAID Clinical Genomics Program. National Institutes of Health)
Lenardo, M. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Luthers, Christopher R. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences)
Bauman, Bradly M. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences)
Shafer, Samantha (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Zheng, Lixin (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Zhang, Zinan (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Kubo, Satoshi (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Chauvin, Samuel D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Lenardo, Michael (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH)
Lack, Justin (NIAID Collaborative Bioinformatics Resource. Frederick National Laboratory for Cancer Research. Leidos Biomedical Research. Inc.)
Karlins, Eric (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica))
Hupalo, Daniel M. (American Genome Center. Uniformed Services University of the Health Sciences)
Rosenberger, John (American Genome Center. Uniformed Services University of the Health Sciences)
Sukumar, Gauthaman (American Genome Center. Uniformed Services University of the Health Sciences)
Wilkerson, Matthew D. (American Genome Center. Uniformed Services University of the Health Sciences)
Zhang, Xijun (American Genome Center. Uniformed Services University of the Health Sciences)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3. 5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
Ayudas:	European Commission 84110 Ministerio de Ciencia e Innovación TC-2017-6471-1 Instituto de Salud Carlos III COV20_01333 Instituto de Salud Carlos III COV20_01334
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Asymptomatic Infections ; Betacoronavirus ; Child ; Child, Preschool ; Coronavirus Infections ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Humans ; Infant ; Interferon Regulatory Factor-7 ; Interferon Type I ; Loss of Function Mutation ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral ; Receptor, Interferon alpha-beta ; Toll-Like Receptor 3 ; Young Adult
Publicado en:	Science, Vol. 370 Núm. 6515 (23 2020) , p. eabd4570, ISSN 1095-9203

DOI: 10.1126/science.abd4570
PMID: 32972995

18 p, 1.3 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
Artículos > Artículos publicados