Outcome of hospitalization for COVID-19 in patients with interstitial lung disease an international multicenter study
Drake, Thomas M. (University of Edinburgh. Usher Institute)
Docherty, Annemarie Beth (University of Edinburgh. Usher Institute)
Harrison, Ewen Munro (University of Edinburgh. Usher Institute)
Quint, Jennifer (National Heart and Lung Institute. Imperial College (Londres, Regne Unit))
Adamali, Huzaifa I. (University of Bristol (Bristol, Regne Unit))
Agnew, Sarah (Liverpool Interstitial Lung Disease Service. Aintree site. Liverpool University Hospitals NHS Foundation Trust (Liverpool, Regne Unit))
Babu, Suresh K. (Queen Alexandra Hospital (Portsmouth, Regne Unit))
Barber, Christopher Michael (Northern General Hospital (Sheffield, Regne Unit))
Barratt, Shaney (University of Bristol (Bristol, Regne Unit))
Bendstrup, Elisabeth (Aarhus University Hospital (Aarhus, Dinamarca))
Bianchi, Stephen Mark (Northern General Hospital (Sheffield, Regne Unit))
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Chaudhuri, Nazia (University of Manchester (Manchester, Regne Unit))
Chua, Felix (Royal Brompton and Harefield NHS Foundation Trust (Londres, Regne Unit))
Coker, Robina Kate (Hammersmith Hospital (Londres, Regne Unit))
Chang, William Y. C. (Nottingham University Hospitals NHS Trust (Nottingham, Regne Unit))
Crawshaw, Anjali P. (Queen Elizabeth Hospital (Birmingham, Regne Unit))
Crowley, Louise E. (University of Birmingham)
Dosanjh, Davinder P. S. (Queen Elizabeth Hospital (Birmingham, Regne Unit))
Fiddler, Christine A. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Forrest, Ian A. (Royal Victoria Infirmary)
George, Peter M. (Royal Brompton and Harefield NHS Foundation Trust (Londres, Regne Unit))
Gibbons, Michael (South West Peninsula ILD Network. Royal Devon & Exeter Foundation NHS Trust (Exeter, Regne Unit))
Groom, Katherine (Hammersmith Hospital (Londres, Regne Unit))
Haney, Sarah (Northumbria Specialist Emergency Care Hospital. Northumbria Healthcare NHS Foundation Trust(Cramlington, Regne Unit))
Hart, Simon P. (Respiratory Research Group. Hull York Medical School. Castle Hill Hospital (Hull, Regne Unit))
Heiden, Emily (University Hospital Southampton NHS Foundation Trust (Portsmouth, Regne Unit))
Henry, Michael Thomas (Cork University Hospital (Cork, Irlanda))
Ho, Ling-Pei (Oxford Interstitial Lung Disease Service. Oxford University Hospitals NHS Foundation Trust (Oxford, Regne Unit))
Hoyles, Rachel K. (Oxford Interstitial Lung Disease Service. Oxford University Hospitals NHS Foundation Trust (Oxford, Regne Unit))
Hutchinson, John P. (King's Mill Hospital (Nottinghamshire, Regne Unit))
Hurley, Killian (Beaumont Hospital (Dublín, Irlanda))
Jones, Mark (National Institute for Health Research. Southampton Biomedical Research Centre & Clinical and Experimental Sciences. University of Southampton (Southampton, Regne Unit))
Jones, Steve (Action for Pulmonary Fibrosis. Stuart House (Peterborough, Regne Unit))
Kokosi, Maria A. (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Kreuter, Michael (Center for Interstitial and Rare Lung Diseases. Pneumology. Thoraxklinik. University of Heidelberg. German Center for Lung Research (Mainz, Alemanya))
MacKay, Laura S. (Northumbria Specialist Emergency Care Hospital. Northumbria Healthcare NHS Foundation Trust (Cramlington, Regne Unit))
Mahendran, Siva (Kingston Hospital NHS Foundation Trust (Kingston Upon Thames, Regne Unit))
Margaritopoulos, George A. (ILD Unit. Manchester University Hospital NHS Foundation Trust. Wythenshawe Hospital (Londres, Regne Unit))
Molina Molina, Maria (Institut d'Investigació Biomèdica de Bellvitge)
Molyneaux, Philip L. (National Heart and Lung Institute. Imperial College (Londres, Regne Unit))
O'Brien, Aidan (University Hospital Limerick (Limerick, Irlanda))
O'Reilly, Katherine (Mater Misericordiae University Hospital (Dublín, Irlanda))
Packham, Alice (Queen Elizabeth Hospital (Birmingham, Regne Unit))
Parfrey, Helen (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Poletti, Venerino (Morgagni Hospital (Bolonya, Itàlia))
Porter, Joanna C. (UCL Respiratory. University College London. ILD Service. University College London Hospitals NHS Foundation Trust (Londres, Regne Unit))
Renzoni, Elisabetta (Royal Brompton and Harefield NHS Foundation Trust (Londres, Regne Unit))
Rivera-Ortega, Pilar (ILD Unit. Manchester University Hospital NHS Foundation Trust. Wythenshawe Hospital (Manchester,, Regne Unit))
Russell, Anne Marie (Imperial Healthcare NHS Trust. St. Mary's Hospital. The Bays (Birmingham, Regne Unit))
Saini, Gauri (Nottingham University Hospitals NHS Trust (Nottingham, Regne Unit))
Spencer, Lisa (Liverpool Interstitial Lung Disease Service. Aintree site. Liverpool University Hospitals NHS Foundation Trust (Liverpool, Regne Unit))
Stella, Giulia Maria (Fondazione IRCCS Policlinico San Matteo (Itàlia))
Stone, Helen (University Hospital North Midlands NHS Trust. Royal Stoke University Hospital (Stoke-on-Trent, Regne Unit))
Sturney, Sharon Coral (Royal United Hospitals Bath NHS Foundation Trust (Bath, Regne Unit))
Thickett, David (University of Birmingham)
Thillai, Muhunthan (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Wallis, Timothy J. M. (National Institute for Health Research (NIHR). Southampton Biomedical Research Centre & Clinical and Experimental Sciences. University of Southampton (Southampton, Regne Unit))
Ward, Kate Anna (National Heart and Lung Institute. Imperial College (Londres, Regne Unit))
Wells, Athol Umfrey (Royal Brompton and Harefield NHS Foundation Trust (Londres, Regne Unit))
West, Alex G. (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Wickremasinghe, Melissa I. Y. (Imperial Healthcare NHS Trust. St. Mary's Hospital. The Bays (Londres, Regne Unit))
Woodhead, Felix Alexander (Institute of Lung Health. Interstitial Lung Disease Unit. Glenfield Hospital (Leicester, Regne Unit))
Hearson, Glenn (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham (Nottingham, Regne Unit))
Howard, Lucy S. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham (Nottingham, Regne Unit))
Baillie, John Kenneth (Intensive Care Unit. Royal Infirmary of Edinburgh)
Openshaw, Peter (National Heart and Lung Institute. Imperial College (Londres, Regne Unit))
Semple OBE , Malcolm G. (Respiratory Medicine. Alder Hey Children's Hospital (Liverpool, Regne Unit))
Stewart, Iain D. (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham (Nottingham, Regne Unit))
Jenkins, Gisli (NIHR Biomedical Research Centre. Respiratory Research Unit. University of Nottingham (Nottingham, Regne Unit))
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population. Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to the hospital with COVID-19 between March 1 and May 1, 2020, was undertaken and compared with patients without ILD, obtained from the ISARIC4C (International Severe Acute Respiratory and Emerging Infection Consortium Coronavirus Clinical Characterisation Consortium) cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished idiopathic pulmonary fibrosis from non-idiopathic pulmonary fibrosis ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to the hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching, patients with ILD with COVID-19 had significantly poorer survival (hazard ratio [HR], 1. 60; confidence interval, 1. 17-2. 18; P = 0. 003) than age-, sex-, and comorbidity-matched controls without ILD. Patients with an FVC of,80% had an increased risk of death versus patients with FVC.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Idiopathic pulmonary fibrosis ; Interstitial lung disease ; Lung function ; Obesity
Publicat a:	American Journal of Respiratory and Critical Care Medicine, Vol. 202 Núm. 12 (15 2020) , p. 1656-1665, ISSN 1535-4970

DOI: 10.1164/rccm.202007-2794OC
PMID: 33007173

10 p, 772.3 KB

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