Chronic Effect of a Cafeteria Diet and Intensity of Resistance Training on the Circulating Lysophospholipidome in Young Rats
Suárez-García, Susana (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia)
Caimari, Antoni (Eurecat. Centre Tecnològic de Catalunya. Unitat de Nutrició i Salut)
Del Bas, Josep Maria (Eurecat. Centre Tecnològic de Catalunya. Unitat de Nutrició i Salut)
Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències)
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Institut de Neurociències)
Suárez Recio, Manuel (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia)
Torres-Fuentes, Cristina (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia)
Arola, Lluís (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia)

Date:	2021
Abstract:	The daily practice of physical exercise and a balanced diet are recommended to prevent metabolic syndrome (MetS). As MetS is a multifactorial disorder associated with the development of serious diseases, the advancement of comprehensive biomarkers could aid in an accurate diagnosis. In this regard, it is known that gut microbiota is altered in MetS, and especially, lipid metabolites species are highly modified, thus emerging as potential biomarkers. In preliminary studies, we observed that alterations in serum lysoglycerophospholipids (Lyso-PLs) were shared between animals with diet-induced MetS and those performing resistance exercises assiduously. Therefore, our objective was the targeted determination of the lysophospholipidome in young rats fed a standard (ST) or a cafeteria diet (CAF) and submitted to different training intensities to evaluate its potential as a biomarker of a detrimental lifestyle. Targeted metabolomics focused on lysophosphatidylcholines (Lyso-PCs) and lysophosphatidylethanolamines (Lyso-PEs) and multivariate statistics were used to achieve an integral understanding. Chronic intake of CAF altered the serological levels of both lipid subclasses. Twenty-two Lyso-PLs were significantly altered by CAF, from which we selected Lyso-PCs (14:0), (17:1) and (20:2) and Lyso-PEs (18:2) and (18:3) as they were enough to achieve an optimal prediction. The main effect of physical training was decreased Lyso-PEs levels with disparities among training intensities for each diet. We concluded that an examination of the lysophospholipidome reveals the general state of the metabolome in young female rats, especially due to intake of an MetS-inducing diet, thus highlighting the importance of this family of compounds in lipid disorders.
Grants:	Ministerio de Economía y Competitividad AGL2013-40707-R Ministerio de Ciencia e Innovación PSI2011-29807-C02 Agència de Gestió d'Ajuts Universitaris i de Recerca 2016FI_B200070
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Lysoglycerophospholipids ; Metabolic syndrome ; Cafeteria diet ; Resistance training
Published in:	Metabolites, Vol. 11 (july 2021) , ISSN 2218-1989

DOI: 10.3390/metabo11080471
PMID: 34436412

13 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles