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Pàgina inicial > Articles > Articles publicats > Metal utilization in genome-reduced bacteria : |
Data: | 2021 |
Resum: | Mycoplasmas are parasitic bacteria with streamlined genomes and complex nutritional requirements. Although iron is vital for almost all organisms, its utilization by mycoplasmas is controversial. Despite its minimalist nature, mycoplasmas can survive and persist within the host, where iron availability is rigorously restricted through nutritional immunity. In this review, we describe the putative iron-enzymes, transporters, and metalloregulators of four relevant human mycoplasmas. This work brings in light critical differences in the mycoplasma-iron interplay. Mycoplasma penetrans, the species with the largest genome (1. 36 Mb), shows a more classic repertoire of iron-related proteins, including different enzymes using iron-sulfur clusters as well as iron storage and transport systems. In contrast, the iron requirement is less apparent in the three species with markedly reduced genomes, Mycoplasma genitalium (0. 58 Mb), Mycoplasma hominis (0. 67 Mb) and Mycoplasma pneumoniae (0. 82 Mb), as they exhibit only a few proteins possibly involved in iron homeostasis. The multiple facets of iron metabolism in mycoplasmas illustrate the remarkable evolutive potential of these minimal organisms when facing nutritional immunity and question the dependence of several human-infecting species for iron. Collectively, our data contribute to better understand the unique biology and infective strategies of these successful pathogens. |
Ajuts: | Agencia Estatal de Investigación BIO2017-84166-R Agencia Estatal de Investigación PID2020-120222GB-I00 Instituto de Salud Carlos III PI19/01911 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | ABC, ATP-binding cassette ; ECF, energy-coupling factor ; Fur, ferric uptake regulator ; Hrl, histidine-rich lipoprotein ; Mge, Mycoplasma genitalium ; Mho, Mycoplasma hominis ; Mpe, Mycoplasma penetrans ; Mpn, Mycoplasma pneumonia ; PDB, protein data bank ; RNR, ribonucleotide reductase ; XRF, X-ray fluorescence ; ZIP, zinc-iron permease ; Mycoplasmas ; Mollicutes ; Metal acquisition ; Iron homeostasis ; Metalloenzyme ; ECF transporter |
Publicat a: | Computational and Structural Biotechnology Journal, Vol. 19 (2021) , p. 5752-5761, ISSN 2001-0370 |
10 p, 1.4 MB |