Association of serum interleukin-6 and C-reactive protein with depressive and adjustment disorders in COVID-19 inpatients
Iglesias-González, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Boigues Pons, Marc (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sanagustin, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Giralt López, Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Cuevas-Esteban, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Diez-Quevedo, Crisanto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2021
Resum:	Immune mechanisms are part of the pathophysiology of mental disorders, although their role remains controversial. In depressive disorders a chronic low-grade inflammatory process is observed, with higher interleukin-6 (IL-6) values. Furthermore, in SARS-CoV2 infection, which is closely related to depressive disorders, there is a proinflammatory cascade of cytokines that causes systemic inflammation. The present study evaluates the relationship between IL-6 and C-reactive protein (CRP) serum levels and the presence of depressive and adjustment disorders in a sample of 1851 patients admitted to hospital for SARS-CoV2 infection from March to November 2020. Concentrations of IL-6 and CRP were determined within the first 72 ​h at admission and compared among groups of patients according to previous history and current presence of depression or adjustment disorders. IL-6 serum levels were significantly higher in the group of patients with depression and adjustment disorders compared to patients without such disorders (114. 25 ​pg/mL (SD, 225. 44) vs. 86. 41 (SD, 202. 97)), even after adjusting for several confounders. Similar results were obtained for CRP (103. 94 ​mg/L (SD, 91. 16) vs. 90. 14 (SD, 85. 73)). The absolute levels of IL-6 and CRP were higher than those of previous depression studies, and differences were only found for the subgroup of De Novo depressive or adjustment disorders. Serum concentrations of IL-6 and CRP are higher in COVID-19 patients with De Novo but not persistent depressive or adjustment disorders. Clinical features such as fatigue, asthenia, anhedonia, or anxiety can be the basis for this finding.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Inflammation ; Immunity ; Depression ; Anxiety ; COVID-19 ; Cytokines
Publicat a:	Brain, Behavior, & Immunity - Health, Vol. 19 (february 2022) , ISSN 2666-3546

DOI: 10.1016/j.bbih.2021.100405
PMID: 34927104

7 p, 281.2 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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