FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b
Coccia, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)
Masanas, Marc (Hospital Universitari Vall d'Hebron)
López-Soriano, Joaquín (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segura, Miguel F. (Hospital Universitari Vall d'Hebron)
Comella i Carnicé, Joan Xavier 1963- (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pérez-García, M. Jose (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2020
Abstract:	Apoptosis plays an important role during development, control of tissue homeostasis and in pathological contexts. Apoptosis is executed mainly through the intrinsic pathway or the death receptor pathway, i. e. , extrinsic pathway. These processes are tightly controlled by positive and negative regulators that dictate pro- or anti-apoptotic death receptor signaling. One of these regulators is the Fas Apoptotic Inhibitory Molecule (FAIM). This death receptor antagonist has two main isoforms, FAIM-S (short) which is the ubiquitously expressed, and a longer isoform, FAIM-L (long), which is mainly expressed in the nervous system. Despite its role as a death receptor antagonist, FAIM also participates in cell death-independent processes such as nerve growth factor-induced neuritogenesis or synaptic transmission. Moreover, FAIM isoforms have been implicated in blocking the formation of protein aggregates under stress conditions or de-regulated in certain pathologies such as Alzheimer's and Parkinson's diseases. Despite the role of FAIM in physiological and pathological processes, little is known about the molecular mechanisms involved in the regulation of its expression. Here, we seek to investigate the post-transcriptional regulation of FAIM isoforms by microRNAs (miRNAs). We found that miR-206, miR-1-3p, and miR-133b are direct regulators of FAIM expression. These findings provide new insights into the regulation of FAIM and may provide new opportunities for therapeutic intervention in diseases in which the expression of FAIM is altered.
Grants:	Agencia Estatal de Investigación SAF2016-80236-R Agencia Estatal de Investigación PID2019-107286RB-I00 Ministerio de Sanidad y Consumo CB06/05/1104 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-996 Ministerio de Educación, Cultura y Deporte FPU16/01099
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Microrna ; Neurodegenerative diseases ; Nervous system ; Death receptor ; FAIM ; Fas apoptotic inhibitory molecule
Published in:	Frontiers in Cell and Developmental Biology, Vol. 8 (december 2020) , ISSN 2296-634X

DOI: 10.3389/fcell.2020.584606
PMID: 33425889

9 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles