Greater male than female variability in regional brain structure across the lifespan
Wierenga, Lara M. (Leiden Institute for Brain and Cognition)
Doucet, Gaelle E. (Boys Town National Research Hospital)
Dima, Danai (King's College London)
Agartz, Ingrid (Stockholm County Council)
Aghajani, Moji (Leiden University)
Akudjedu, Theophilus N. (Bournemouth University)
Albajes-Eizagirre, Anton (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Alnæs, Dag (Oslo University Hospital (Oslo, Noruega))
Alpert, Kathryn I (Northwestern University Feinberg School of Medicine)
Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega))
Anticevic, Alan (Yale University)
Asherson, Philip (King's College London)
Banaschewski, Tobias (University of Heidelberg, Medical Faculty Mannheim)
Bargalló, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Baumeister, Sarah (University of Heidelberg, Medical Faculty Mannheim)
Baur-Streubel, Ramona (Würzburg University)
Bertolino, Alessandro (University of Bari Aldo Moro)
Bonvino, Aurora (University of Bari Aldo Moro)
Boomsma, Dorret I (Vrije Universiteit Amsterdam)
Borgwardt, Stefan (University of Lübeck)
Bourque, Josiane (CHU Sainte-Justine Research Center)
den Braber, A (Amsterdam UMC, Location VUMC)
Brandeis, Daniel (University and ETH Zurich)
Breier, Alan (Indiana University School of Medicine)
Brodaty, Henry (University of New South Wales)
Brouwer, Rachel M. (Utrecht University)
Buitelaar, Jan (Karakter Child and Adolescent Psychiatry University Centre)
Busatto, Geraldo F. (Universidade de São Paulo)
Calhoun, Vince (Georgia State, Georgia Tech)
Canales-Rodriguez, Erick Jorge (Centro de Investigación Biomédica en Red de Salud Mental)
Cannon, Dara M. (National University of Ireland Galway)
Caseras, Xavier (Cardiff University)
Castellanos, Francisco X (Nathan Kline Institute for Psychiatric Research)
Chaim-Avancini, Tiffany M. (Universidade de São Paulo)
Ching, Christopher R. K. (University of Southern California)
Clark, Vincent P. (Mind Research Network)
Conrod, Patricia (University of Montreal)
Conzelmann, Annette (PFH - Private University of Applied Sciences)
Crivello, Fabrice (Institut des Maladies Neurodégénératives)
Davey, Christopher (Orygen)
Dickie, Erin W. (University of Toronto)
Ehrlich, Stefan (University Hospital C.G. Carus)
van't Ent, Dennis (Vrije Universiteit Amsterdam)
Fisher, Simon E. (Radboud University)
Fouche, Jean-Paul (University of Cape Town)
Franke, Barbara (Radboud University Medical Center)
Fuentes-Claramonte, Paola (Centro de Investigación Biomédica en Red de Salud Mental)
de Geus, Eco J. C. (Vrije Universiteit Amsterdam)
Di Giorgio, Annabella (IRCCS Casa Sollievo della Sofferenza)
Glahn, David C. (Hartford Hospital)
Gotlib, Ian H. (Stanford University)
Grabe, Hans J. (Site Rostock/Greifswald)
Gruber, Oliver (Heidelberg University Hospital (Alemanya))
Gruner, Patricia (Yale University)
Gur, Raquel E. (Children's Hospital of Philadelphia (Pennsilvània))
Gur, Ruben C. (University of Pennsylvania)
Gurholt, Tiril Pedersen (Oslo University Hospital (Oslo, Noruega))
de Haan, Lieuwe (Amsterdam UMC)
Haatveit, Beathe (Oslo University Hospital (Oslo, Noruega))
Harrison, Ben J. (The University of Melbourne)
Hartman, Catharina A. (University of Groningen, University Medical Center Groningen)
Hatton, Sean N. (University of California San Diego)
Heslenfeld, Dirk J. (Vrije Universiteit Amsterdam)
van den Heuvel, Odile A. (Vrije Universiteit Amsterdam)
Hickie, Ian B. (University of Sydney)
Hoekstra, Pieter J. (University of Groningen, University Medical Center Groningen)
Hohmann, Sarah (University of Heidelberg, Medical Faculty Mannheim)
Holmes, Avram J. (Massachusetts General Hospital (Boston))
Hoogman, Martine (Radboud University Medical Center)
Hosten, Norbert (University Medicine Greifswald)
Howells, Fleur M. (University of Cape Town)
Hulshoff Pol, Hilleke E. (Utrecht University)
Huyser, Chaim (Amsterdam UMC Department of Child and Adolescent Psychiatry)
Jahanshad, Neda (University of Southern California)
James, Anthony (Warneford Hospital)
Jiang, Jiyang (University of New South Wales)
Jönsson, Erik G. (Stockholm County Council)
Joska, John A. (University of Cape Town)
Kalnin, Andrew J. (The Ohio State University College of Medicine)
Klein, Marieke (Radboud University Medical Center)
Koenders, Laura (Amsterdam UMC)
Kolskår, Knut K. (Sunnaas Rehabilitation Hospital HT)
Krämer, Bernd (Heidelberg University Hospital (Alemanya))
Kuntsi, Jonna (King's College London)
Lagopoulos, Jim (University of the Sunshine Coast)
Lazaro, Luisa (Universitat de Barcelona)
Lebedeva, Irina (Mental Health Research Center)
Lee, Phil H. (Harvard Medical School)
Lochner, Christine (Stellenbosch University)
Machielsen, Marise W. J. (Academic Medical Center)
Maingault, Sophie (Université de Bordeaux)
Martin, Nicholas G. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Martínez-Zalacaín, Ignacio (Universitat de Barcelona)
Mataix-Cols, David (Stockholm County Council)
Mazoyer, Bernard (Bordeaux University Hospital (França))
McDonald, Brenna C. (Indiana University School of Medicine)
McDonald, Colm (National University of Ireland Galway)
McIntosh, Andrew M.. (University of Edinburgh)
McMahon, Katie L. (Queensland University of Technology (QUT))
McPhilemy, Genevieve (National University of Ireland Galway)
van der Meer, Dennis (Maastricht University)
Menchón, José M. (Universitat de Barcelona)
Naaijen, Jilly (Radboud University Medical Centre)
Nyberg, Lars (Umeå University)
Oosterlaan, Jaap (Vrije Universiteit Amsterdam)
Paloyelis, Yannis (King's College London)
Pauli, Paul (University of Würzburg)
Pergola, Giulio (Johns Hopkins Medical Campus)
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental)
Portella, Maria J.. (Institut d'Investigació Biomèdica Sant Pau)
Radua, Joaquim (King's College London)
Reif, Andreas (University Hospital of Frankfurt (Alemanya))
Richard, Geneviève (Oslo University Hospital (Oslo, Noruega))
Roffman, Joshua L. (Harvard Medical School)
Rosa, Pedro G. P. (Universidade de São Paulo)
Sacchet, Matthew D. (Harvard Medical School)
Sachdev, Perminder S. (Prince of Wales Hospital (Australia))
Salvador, Raymond (Centro de Investigación Biomédica en Red de Salud Mental)
Sarró, Salvador (Centro de Investigación Biomédica en Red de Salud Mental)
Satterthwaite, Theodore D. (University of Pennsylvania)
Saykin, Andrew J. (Indiana Alzheimer Disease Center)
Serpa, Mauricio H. (Universidade de São Paulo)
Sim, Kang (National University of Singapore)
Simmons, Andrew (Psychology and Neurology, King's College London)
Smoller, Jordan W. (Massachusetts General Hospital (Boston))
Sommer, Iris E. (University Medical Center Groningen)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Stein, Dan J. (University of Cape Town)
Strike, Lachlan (University of Queensland)
Szeszko, Philip R. (James J. Peters VA Medical Center)
Temmingh, Henk S. (University of Cape Town)
Thomopoulos, Sophia I (University of Southern California)
Tomyshev, Alexander S. (Mental Health Research Center)
Trollor, Julian N. (University of New South Wales)
Uhlmann, Anne (Faculty of Medicine Carl Gustav Carus of TU Dresden)
Veer, Ilya M. (Humboldt-Universität zu Berlin)
Veltman, Dick J. (Amsterdam UMC, location VUMC)
Voineskos, Aristotle (University of Toronto)
Völzke, Henry (DZD (German Center for Diabetes Research), partner site Greifswald)
Walter, Henrik (Humboldt-Universität zu Berlin)
Wang, Lei (Northwestern University Feinberg School of Medicine)
Wang, Yang (Medical College of Wisconsin)
Weber, Bernd (University Hospital Bonn (Bonn, Alemanya))
Wen, Wei (University of New South Wales)
West, John D. (Indiana University School of Medicine)
Westlye, Lars T. (University of Oslo)
Whalley, Heather (Royal Edinburgh Hospital)
Williams, Steven C. R. (King's College London)
Wittfeld, Katharina (Site Rostock/Greifswald)
Wolf, Daniel H. (University of Pennsylvania)
Wright, Margaret J. (University of Queensland)
Yoncheva, Yuliya N. (Hassenfeld Children's Hospital at NYU Langone)
Zanetti, Marcus V (Hospital Sírio-Libanês)
Ziegler, Georg C. (University of Würzburg)
de Zubicaray, Greig (Queensland University of Technology (QUT))
Thompson, Paul M. (University of Southern California)
Crone, Eveline A. (Erasmus University Rotterdam)
Frangou, Sophia (University of British Columbia)
Tamnes, Christian K. (University of Oslo)

Data:	2020
Resum:	For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
Ajuts:	European Commission 667302 European Commission 643051 European Commission 667302 European Commission 602805
Nota:	Altres ajuts: The Marató TV3 Foundation #091710
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Human Brain Mapping, Vol. 43 (october 2020) , p. 470-499, ISSN 1065-9471

DOI: 10.1002/hbm.25204
PMID: 33044802

30 p, 4.3 MB

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