Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock
Hänninen, Mikko (Minerva Foundation Institute for Medical Research (Finland))
Jäntti, Toni (Helsinki University Hospital (Finlàndia))
Tolppanen, Heli (Helsinki University Hospital (Finlàndia))
Segersvärd, Heli (Minerva Foundation Institute for Medical Research (Finland))
Tarvasmäki, Tuukka (Helsinki University Hospital (Finlàndia))
Lassus, Johan (Helsinki University Hospital (Finlàndia))
Vausort, Mélanie (Luxembourg Institute of Health)
Devaux, Yvan (Luxembourg Institute of Health)
Sionis, Alessandro (Institut d'Investigació Biomèdica Sant Pau)
Tikkanen, Ilkka (Helsinki University Hospital (Finlàndia))
Harjola, Veli-Pekka (Helsinki University Hospital (Finlàndia))
Lakkisto, Päivi (Helsinki University Hospital (Finlàndia))
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Cardiogenic shock (CS) is a life-threatening emergency. New biomarkers are needed in order to detect patients at greater risk of adverse outcome. Our aim was to assess the characteristics of miR-21-5p, miR-122-5p, and miR-320a-3p in CS and evaluate the value of their expression levels in risk prediction. Circulating levels of miR-21-5p, miR-122-5p, and miR-320a-3p were measured from serial plasma samples of 179 patients during the first 5-10 days after detection of CS, derived from the CardShock study. Acute coronary syndrome was the most common cause (80%) of CS. Baseline (0 h) levels of miR-21-5p, miR-122-5p, and miR-320a-3p were all significantly elevated in nonsurvivors compared to survivors (p < 0. 05 for all). Above median levels at 0h of each miRNA were each significantly associated with higher lactate and alanine aminotransferase levels and decreased glomerular filtration rates. After adjusting the multivariate regression analysis with established CS risk factors, miR-21-5p and miR-320a-3p levels above median at 0 h were independently associated with 90-day all-cause mortality (adjusted hazard ratio 1. 8 (95% confidence interval 1. 1-3. 0), p = 0. 018; adjusted hazard ratio 1. 9 (95% confidence interval 1. 2-3. 2), p = 0. 009, respectively). In conclusion, circulating plasma levels of miR-21-5p, miR-122-5p, and miR-320a-3p at baseline were all elevated in nonsurvivors of CS and associated with markers of hypoperfusion. Above median levels of miR-21-5p and miR-320a-3p at baseline appear to independently predict 90-day all-cause mortality. This indicates the potential of miRNAs as biomarkers for risk assessment in cardiogenic shock.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiogenic shock ; Microrna ; Mortality ; Prognosis
Published in:	International journal of molecular sciences, Vol. 21 (october 2020) , ISSN 1422-0067

DOI: 10.3390/ijms21217925
PMID: 33114482

12 p, 975.8 KB

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Articles > Research articles
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