Emerging Roles of Lysyl Oxidases in the Cardiovascular System : New Concepts and Therapeutic Challenges
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau)
Varona, Saray (Institut d'Investigació Biomèdica Sant Pau)
Cañes Esteve, Laia (Institut d'Investigació Biomèdica Sant Pau)
Galán, María (Institut d'Investigació Biomèdica Sant Pau)
Briones, Ana (Hospital Universitario La Paz (Madrid))
Cachofeiro, Victoria (Universidad Complutense de Madrid)
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, differentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular stiffness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets.
Grants:	Instituto de Salud Carlos III RTI2018-094727-B-100 Instituto de Salud Carlos III PI18/0919 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-00333 Ministerio de Economía y Competitividad CP15/00126
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Lysyl oxidases ; Cardiovascular diseases ; Atherosclerosis ; Aortic aneurysm ; Vascular calcification ; Vascular stiffness ; Myocardial fibrosis
Published in:	Biomolecules, Vol. 9 (october 2019) , ISSN 2218-273X

DOI: 10.3390/biom9100610
PMID: 31615160

21 p, 3.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles