Primary Orthostatic Tremor : Experience of Perampanel Use in 20 Patients
Gironell, Alexandre (Institut d'Investigació Biomèdica Sant Pau)
Marín Lahoz, Juan (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Primary orthostatic tremor (POT) is a rare disorder for which current treatments are largely ineffective. Following up on our recent report of complete resolution of POT symptoms in a patient using low doses of perampanel, we describe our experience of perampanel in 20 patients. Twenty patients whose neurologists prescribed perampanel were recruited. Initial dose was 2 mg/day, which was increased to 4 mg/day after the first month. Treatment efficacy was self-scored from +3 to -3 at 1 and 3 months. Eight patients withdrew due to adverse effects. Of the 12 patients who completed the study, 92% indicated that their POT symptoms had improved after 1 month, with 75% indicating moderate to marked improvement (mean score 1. 9 ± 0. 9). This improvement was not sustained by follow-up at 3 months (mean score 0. 9 ± 1. 3). A rebound of POT symptoms that lasted 2-6 weeks was observed in most patients who withdrew. Our experience with this series of cases points to the potential of low-dose perampanel as a treatment for POT, although poor tolerance and the possibility of a non-persistent therapeutic benefit need to be considered. Controlled studies are needed to confirm these findings.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Orthostatic tremor ; Primary orthostatic tremor ; Tremor ; Perampanel ; Unsteadiness
Published in:	Tremor and Other Hyperkinetic Movements, Vol. 9 (october 2019) , ISSN 2160-8288

DOI: 10.7916/tohm.v0.720
PMID: 31673479

4 p, 772.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles