A Biomarker to differentiate between primary and cocaine-induced major depression in cocaine use disorder : the role of platelet IRAS/Nischarin (I-Imidazoline receptor)
Keller, Benjamin (Universitat de les Illes Balears)
Mestre-Pinto, Joan-Ignasi (Institut Hospital del Mar d'Investigacions Mèdiques)
Álvaro-Bartolomé, María (Universitat de les Illes Balears)
Martinez-Sanvisens, Diana (Institut Hospital del Mar d'Investigacions Mèdiques)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Fuster, M. Julia (Universitat de les Illes Balears)
García-Sevilla, Jesús A. (Universitat de les Illes Balears)
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2017
Abstract:	The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). Specific biomarkers are needed to improve diagnoses and therapeutic approaches in this dual pathology. Platelet biomarkers [5-HT receptor and imidazoline receptor antisera selected (IRAS)/nischarin] were assessed by Western blot in subjects with CUD and primary MDD (n = 16) or CUD-induced MDD (n = 9; antidepressant free, AD−; antidepressant treated, AD+) and controls (n = 10) at basal level and/or after acute tryptophan depletion (ATD). Basal platelet 5-HT receptor (monomer) was reduced in comorbid CUD/MDD subjects (all patients: 43%) compared to healthy controls, and this down-regulation was independent of AD medication (decreases in AD−: 47%, and in AD+: 40%). No basal differences were found for IRAS/nischarin contents in AD+ and AD− comorbid CUD/MDD subjects. The comparison of IRAS/nischarin in the different subject groups during/after ATD showed opposite modulations (i. e. , increases and decreases) in response to low plasma tryptophan levels with significant differences discriminating between the subgroups of CUD with primary MDD and CUD-induced MDD. These specific alterations suggested that platelet IRAS/nischarin might be useful as a biomarker to discriminate between primary and CUD-induced MDD in this dual pathology.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Platelet biomarker ; IRAS/nischarin ; Cocaine use disorder ; Major depressive disorder ; Cocaine-induced depression ; Acute tryptophan depletion ; Antidepressant drugs
Published in:	Frontiers in psychiatry, Vol. 8 (december 2017) , art. 258, ISSN 1664-0640

DOI: 10.3389/fpsyt.2017.00258
PMID: 29326609

9 p, 833.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles