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Página principal > Artículos > Artículos publicados > Intrinsically regulated learning is modulated by synaptic dopamine signaling |
Fecha: | 2018 |
Resumen: | We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback -modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al. , 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success. |
Ayudas: | Instituto de Salud Carlos III CP04/00121 Ministerio de Economía, Industria y Competitividad PSI2011-29219 Ministerio de Economía, Industria y Competitividad AP2010-4179 Ministerio de Economía, Industria y Competitividad PSI2015-69178-P |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Learning ; Reward ; Memory ; Dopamine ; Word learning ; Language ; Human |
Publicado en: | eLife, Vol. 7 (august 2018) , ISSN 2050-084X |
23 p, 809.8 KB |