Restriction Factors : From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1
Colomer-Lluch, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Ruiz, Alba (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Moris, Arnaud (Sorbonne Université, INSERM U1135, CNRS ERL 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris))
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)

Date:	2018
Abstract:	Antiviral restriction factors are host cellular proteins that constitute a first line of defense blocking viral replication and propagation. In addition to interfering at critical steps of the viral replication cycle, some restriction factors also act as innate sensors triggering innate responses against infections. Accumulating evidence suggests an additional role for restriction factors in promoting antiviral cellular immunity to combat viruses. Here, we review the recent progress in our understanding on how restriction factors, particularly APOBEC3G, SAMHD1, Tetherin, and TRIM5α have the cell-autonomous potential to induce cellular resistance against HIV-1 while promoting antiviral innate and adaptive immune responses. Also, we provide an overview of how these restriction factors may connect with protein degradation pathways to modulate anti-HIV-1 cellular immune responses, and we summarize the potential of restriction factors-based therapeutics. This review brings a global perspective on the influence of restrictions factors in intrinsic, innate, and also adaptive antiviral immunity opening up novel research avenues for therapeutic strategies in the fields of drug discovery, gene therapy, and vaccines to control viral infections.
Grants:	Ministerio de Economía y Competitividad PI14/01058 Ministerio de Economía y Competitividad RD16/0025/0041 Ministerio de Economía y Competitividad CPII15/00014
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Restriction factors ; HIV-1 ; Innate immunity ; Adaptive immunity ; Virus ; Degradation pathways ; Immunotherapies
Published in:	Frontiers in immunology, Vol. 9 (december 2018) , ISSN 1664-3224

DOI: 10.3389/fimmu.2018.02876
PMID: 30574147

18 p, 1.9 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles