Changes in PH in exhaled breath condensate after specific bronchial challenge test in patients with chronic hypersensitivity pneumonitis : a prospective study
Ojanguren, Iñigo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cruz Carmona, María Jesús (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Villar, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sanchez-Ortiz, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Morell Brotad, Ferran 1944- (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	The aim of this study was to investigate the influence of the specific inhalation challenge (SIC) on changes of pH values in exhaled breath condensate (EBC) in patients with hypersensitivity pneumonitis (HP). A prospective study of 85 patients with suspected HP, of whom 63 were diagnosed with HP due to exposure to avian or fungal antigens. In all cases, EBC samples were collected before and after completion of the SIC and pH values were determined. Taken as a whole, patients with HP did not present changes in EBC pH after SIC. However, considering only patients with exposure to molds, those diagnosed with HP had a significantly more acid pH post-SIC than those with another diagnosis (p = 0. 011). This fact is not observed in patients exposed to bird's antigens. A ROC curve showed that a reduction in EBC pH of 0. 3 units or more after SIC in patients diagnosed with HP due to exposure to molds had a sensitivity of 30 % (CI: 12. 8 to 54. 3 %) and a specificity of 100 % (CI: 65. 5 to 100 %). EBC pH may be useful in interpreting SIC results in patients with HP, especially in those patients exposed to molds. Further studies are now required to test the validity of these proposals.
Ajuts:	Ministerio de Ciencia e Innovación PI13/01076 Ministerio de Ciencia e Innovación CP12/03101
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Inflammation ; Pulmonary fibrosis ; Environmental exposure
Publicat a:	BMC Pulmonary Medicine, Vol. 15 (september 2015) , ISSN 1471-2466

DOI: 10.1186/s12890-015-0100-5
PMID: 26420256

8 p, 593.4 KB

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