Complex Links between Natural Tuberculosis and Porcine Circovirus Type 2 Infection in Wild Boar
Díez-Delgado, Iratxe (Instituto de Investigación en Recursos Cinegéticos)
Boadella, Mariana (Instituto de Investigación en Recursos Cinegéticos)
Martín-Hernando, MariPaz (Instituto de Investigación en Recursos Cinegéticos)
Barasona, José Ángel (Instituto de Investigación en Recursos Cinegéticos)
Beltrán-Beck, Beatriz (Instituto de Investigación en Recursos Cinegéticos)
González-Barrio, David (Instituto de Investigación en Recursos Cinegéticos)
Sibila, Marina (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Vicente, Joaquín (Instituto de Investigación en Recursos Cinegéticos)
Garrido, Joseba M. (Instituto Vasco de Investigación y Desarrollo Agrario)
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Gortazar, Christian (Instituto de Investigación en Recursos Cinegéticos)

Date:	2014
Abstract:	Individuals in natural populations are exposed to a diversity of pathogens which results in coinfections. The aim of this study was to investigate the relation between natural infection with tuberculosis (TB) due to infection by bacteria of the Mycobacterium tuberculosis complex and porcine circovirus type 2 (PCV2) in free-ranging Eurasian wild boar (Sus scrofa). Apparent prevalence for TB lesions and PCV2 infection was extremely high in all age classes, including piglets (51% for TB; 85. 7% for PCV2). Modeling results revealed that the relative risk of young (less than 2 years old) wild boar to test positive to PCV2 PCR was negatively associated with TB lesion presence. Also, an interaction between TB, PCV2, and body condition was evidenced: in wild boar with TB lesions probability of being PCV2 PCR positive increased with body condition, whereas this relation was negative for wild boar without TB lesions. This study provides insight into the coinfections occurring in free-ranging host populations that are naturally exposed to several pathogens at an early age. Using TB and PCV2 as a case study, we showed that coinfection is a frequent event among natural populations that takes place early in life with complex effects on the infections and the hosts.
Grants:	Ministerio de Economía y Competitividad AGL2011-30041
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	BioMed Research International, Vol. 2014 (june 2014) , ISSN 2314-6141

DOI: 10.1155/2014/765715
PMID: 24991567

8 p, 614.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Research articles
Articles > Published articles