New stimulation device to drive multiple transverse intrafascicular electrodes and achieve highly selective and rich neural responses
Guiho, Thomas (Université de Montpellier. Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier)
López-Álvarez, Victor Manuel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Čvančara, Paul (University of Freiburg. Department of Microsystems Engineering)
Hiairrassary, Arthur (Université de Montpellier. Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier)
Andreu, David (Université de Montpellier. Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier)
Stieglitz, Thomas (University of Freiburg. Department of Microsystems Engineering)
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Guiraud, David (Université de Montpellier. Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier)
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Date:	2021
Abstract:	Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator-called STIMEP-and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes.
Grants:	European Commission 602547
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Stimulation selectivity ; Stimulation device ; Intrafascicular electrode ; Peripheral nerve ; Neuroprosthesis
Published in:	Sensors (Basel, Switzerland), Vol. 21, Issue 21 (November 2021) , art. 7219, ISSN 1424-8220

DOI: 10.3390/s21217219
PMID: 34770527

17 p, 4.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles