Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms
Salvador-Mira, Maria (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche)
Chico, Veronica (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche)
Arostica, Mónica (Pontificia Universidad Católica de Valparaíso. Núcleo Biotecnológico de Curauma)
Guzmán, Fanny (Pontificia Universidad Católica de Valparaíso. Núcleo Biotecnológico de Curauma)
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Perez Garcia-Estañ, Luis (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche)
Ortega-Villaizan, Maria del Mar (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche)
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Date:	2021
Abstract:	One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory ef-fect, and safety of the antiviral therapeutic or prophylactic administration systems currently used.
Grants:	European Commission 639249 Agencia Estatal de Investigación RTI2018-096957-B-C22
Note:	Altres ajuts: Generalitat Valenciana APE/2021/022
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Peptide ; Red blood cells ; Erythrocyte ; Drug delivery ; Ligand ; Prophylactic ; Therapeutic ; Cell-targeting ; Lectin ; Fish
Published in:	International journal of molecular sciences, Vol. 22, Issue 21 (November 2021) , art. 11821, ISSN 1422-0067

DOI: 10.3390/ijms222111821
PMID: 34769254

14 p, 4.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles