Review of the speculative role of co-infections in Streptococcus suis -associated diseases in pigs
Obradovic, Milan R. (University of Montreal. Groupe de Recherche Sur Les Maladies Infectieuses en Production Animale)
Segura, Mariela (University of Montreal. Groupe de Recherche Sur Les Maladies Infectieuses en Production Animale)
Segalés Coma, Joaquim (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Gottschalk, Marcelo (University of Montreal. Groupe de Recherche Sur Les Maladies Infectieuses en Production Animale)

Date:	2021
Abstract:	Streptococcus suis is one of the most important bacterial swine pathogens affecting post-weaned piglets, causing mainly meningitis, arthritis and sudden death. It not only results in severe economic losses but also raises concerns over animal welfare and antimicrobial resistance and remains an important zoonotic agent in some countries. The definition and diagnosis of S. suis -associated diseases can be complex. Should S. suis be considered a primary or secondary pathogen? The situation is further complicated when referring to respiratory disease, since the pathogen has historically been considered as a secondary pathogen within the porcine respiratory disease complex (PRDC). Is S. suis a respiratory or strictly systemic pathogen? S. suis is a normal inhabitant of the upper respiratory tract, and the presence of potentially virulent strains alone does not guarantee the appearance of clinical signs. Within this unclear context, it has been largely proposed that co-infection with some viral and bacterial pathogens can significantly influence the severity of S. suis -associated diseases and may be the key to understanding how the infection behaves in the field. In this review, we critically addressed studies reporting an epidemiological link (mixed infections or presence of more than one pathogen at the same time), as well as in vitro and in vivo studies of co-infection of S. suis with other pathogens and discussed their limitations and possibilities for improvement and proposed recommendations for future studies.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Streptococcus suis ; Co-infections in pigs ; Mixed infections ; Porcine reproductive and respiratory syndrome virus ; Swine influenza virus ; Porcine circovirus 2 ; Bacterial mixed and co-infections ; Porcine respiratory disease complex
Published in:	Veterinary research, Vol. 52 (march 2021) , ISSN 1297-9716

DOI: 10.1186/s13567-021-00918-w
PMID: 33743838

22 p, 1.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Research articles
Articles > Published articles