Engaging Spinal Networks to Mitigate Supraspinal Dysfunction After CP
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann)
Hastings, Susan (SH Pediatric Physical Therapy)
Gad, Parag (SpineX (Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Although children with cerebral palsy seem to have the neural networks necessary to generate most movements, they are markedly dysfunctional, largely attributable to abnormal patterns of muscle activation, often characterized as spasticity, largely reflecting a functionally abnormal spinal-supraspinal connectivity. While it is generally assumed that the etiologies of the disruptive functions associated with cerebral palsy can be attributed primarily to supraspinal networks, we propose that the more normal connectivity that persists between peripheral proprioception-cutaneous input to the spinal networks can be used to guide the reorganization of a more normal spinal-supraspinal connectivity. The level of plasticity necessary to achieve the required reorganization within and among different neural networks can be achieved with a combination of spinal neuromodulation and specific activity-dependent mechanisms. By engaging these two concepts, we hypothesize that bidirectional reorganization of proprioception-spinal cord-brain connectivity to higher levels of functionality can be achieved without invasive surgery.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cerebral palsy ; Spinal cord ; Brain ; Muscle ; EMG
Published in:	Frontiers in Neuroscience, Vol. 15 (april 2021) , ISSN 1662-453X

DOI: 10.3389/fnins.2021.643463
PMID: 33912005

5 p, 888.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles