Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease
Remuzgo-Martínez, Sara (Genetic epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System)
Genre, Fernanda (Genetic epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System)
Pulito-Cueto, Verónica (Genetic epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System)
Atienza-Mateo, Belén (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Mora Cuesta, Víctor Manuel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Iturbe, David (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Fernández Rozas, Sonia María (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Lera-Gómez, Leticia (Genetic epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System)
Alonso Lecue, Pilar (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Ussetti, María Piedad (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Laporta, Rosalía (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Berastegui García, Cristina (Hospital Universitari Vall d'Hebron)
Solé, Amparo (Hospital Universitari i Politècnic La Fe (València))
Pérez González, Virginia Luz (Hospital Universitario 12 de Octubre (Madrid))
De Pablo Gafas, Alicia (Hospital Universitario 12 de Octubre (Madrid))
Gualillo, Oreste (Instituto de Investigación Sanitaria de Santiago (IDIS))
Cifrián, José Manuel (Universidad de Cantabria)
López-Mejías, Raquel (Genetic epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System)
Gonzalez-Gay, MA (University of the Witwatersrand)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.
Grants:	Instituto de Salud Carlos III CP16/00033
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Interstitial lung disease ; Idiopathic interstitial pneumonia ; Vascular endothelial growth factor ; Biomarker ; Genetics
Published in:	Biomedicines, Vol. 9 (april 2021) , ISSN 2227-9059

DOI: 10.3390/biomedicines9050458
PMID: 33922301

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