Home > Articles > Published articles > Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity |
Date: | 2021 |
Abstract: | The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healthy subjects comprised the control group. Lipid profile, hsCRP, and the composition and functional characteristics of VLDL, LDL, and HDL were assessed. At baseline, plasma from subjects with obesity had more triglycerides, VLDLc, and hsCRP, and less HDLc than the control group. These levels progressively normalized after surgery, although triglyceride and hsCRP levels remained higher than those in the controls. The main differences in lipoprotein composition between the obese subjects and the controls were increased apoE in VLDL, and decreased cholesterol and apoJ and increased apoC-III content in HDL. The pro-/anti-atherogenic properties of LDL and HDL were altered in the subjects with obesity at baseline compared with the controls, presenting smaller LDL particles that are more susceptible to modification and smaller HDL particles with decreased antioxidant capacity. Bariatric surgery normalized the composition of lipoproteins and improved the qualitative characteristics of LDL and HDL. In summary, patients with obesity present multiple alterations in the qualitative properties of lipoproteins compared with healthy subjects. Bariatric surgery reverted most of these alterations. |
Grants: | Instituto de Salud Carlos III PI13/00364 Instituto de Salud Carlos III PI16/00471 Instituto de Salud Carlos III CB07/08/0016 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1149 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Obesity ; Bariatric surgery ; Lipoproteins ; Lipoprotein function ; LDL ; HDL ; Apolipoproteins |
Published in: | Journal of clinical medicine, Vol. 10 (april 2021) , ISSN 2077-0383 |
15 p, 1.5 MB |